Gineke Koopmans-Klein1,2, Michel F M Wagemans3, Hans C H Wartenberg4, Yvonne J B Van Megen1, Frank J P M Huygen2. 1. a Medical Department , Mundipharma Pharmaceuticals BV , Hoevelaken , The Netherlands. 2. b Center for Pain Medicine , Erasmus MC , Rotterdam , The Netherlands. 3. c Department of Anesthesiology and Pain Medicine , Reinier de Graaf , Delft , The Netherlands. 4. d Department of Anesthesiology, Academisch Medisch Centrum , University of Amsterdam , Amsterdam , the Netherlands.
Abstract
BACKGROUND: Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC). METHODS: Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone. RESULTS: Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT. CONCLUSION: This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC.
BACKGROUND: Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC). METHODS: Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone. RESULTS: Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT. CONCLUSION: This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC.
Entities:
Keywords:
Opioid induced constipation; laxatives; observational study; oxycodone; pilot study; real-life data
Authors: Joseph V Pergolizzi; Robert B Raffa; Marco Pappagallo; Charles Fleischer; Joseph Pergolizzi; Gianpietro Zampogna; Elizabeth Duval; Janan Hishmeh; Jo Ann LeQuang; Robert Taylor Journal: Patient Prefer Adherence Date: 2017-01-17 Impact factor: 2.711