| Literature DB >> 26639966 |
María Carmona-Iragui1,2, Ana Fernández-Arcos1, Daniel Alcolea1,2, Fabrizio Piazza3,4, Estrella Morenas-Rodriguez1,2, Sofía Antón-Aguirre1,2, Isabel Sala1,2, Jordi Clarimon1,2, Oriol Dols-Icardo1,2, Valle Camacho5, Frederic Sampedro6, Josep Munuera7, Fidel Nuñez-Marin6, Alberto Lleó1,2, Juan Fortea1,2, Beatriz Gómez-Ansón6,8, Rafael Blesa1,2.
Abstract
We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreased Aβ40 and Aβ42. After treatment, focal symptomatology disappeared, and WML and anti-Aβ autoantibodies decreased. The APOEɛ4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.Entities:
Keywords: Biomarkers; Florbetapir-PET; cerebral amyloid angiopathy; cerebrospinal fluid; inflammation
Mesh：
Substances：
Year: 2016 PMID： 26639966 DOI： 10.3233/JAD-150614
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472