Literature DB >> 26639764

Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.

Renata Grzywa1, Łukasz Winiarski1, Mateusz Psurski2, Agata Rudnicka1, Joanna Wietrzyk3, Tadeusz Gajda4, Józef Oleksyszyn5.   

Abstract

This Letter deals with new non-natural diisothiocyanates, their mercapturic acid derivatives-conjugated with N-acetylcysteine as well as their antiproliferative activity towards human colon cancer cell lines and their inhibitory potency towards histone deacetylase activity. The activity of analysed isothiocyanates is not significantly different than their N-acetylcysteine conjugates. In comparison to simple mono-isothiocyanate analogues, aliphatic diisothiocyanates and their conjugates are much more active than the simple presence of two isothiocyanate functionalities could indicate.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Colon cancer cell line; Diisothiocyanate; Histone deacetylase; Mercapturic acid

Mesh：

Substances：

Year:  2015        PMID： 26639764     DOI： 10.1016/j.bmcl.2015.11.045

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids.

Authors:  Kamila Cwiklowska; Mike-Andrew Westhoff; Simon Freisinger; Annika Dwucet; Marc-Eric Halatsch; Uwe Knippschild; Klaus-Michael Debatin; Reinhold Schirmbeck; Lukasz Winiarski; Jozef Oleksyszyn; Christian Rainer Wirtz; Timo Burster
Journal:  Oncol Lett       Date:  2018-08-21       Impact factor: 2.967

2.  Diisothiocyanate-Derived Mercapturic Acids Are a Promising Partner for Combination Therapies in Glioblastoma.

Authors:  Pengfei Xu; Mike-Andrew Westhoff; Amina Hadzalic; Klaus-Michael Debatin; Lukasz Winiarski; Jozef Oleksyszyn; Christian Rainer Wirtz; Uwe Knippschild; Timo Burster
Journal:  ACS Omega       Date:  2022-02-08

Review 3.  Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity.

Authors:  Łukasz Janczewski
Journal:  Molecules       Date:  2022-03-07       Impact factor: 4.411

4.  Synthesis and anti-glioblastoma effects of artemisinin-isothiocyanate derivatives.

Authors:  Chan Myae Nyein; Xiaolin Zhong; Junfeng Lu; Huijuan Luo; Jiamin Wang; Simona Rapposelli; Mingtao Li; Ying Ou-Yang; Rongbiao Pi; Xixin He
Journal:  RSC Adv       Date:  2018-12-07       Impact factor: 3.361

5.  Protective Effects of Pelargonium graveolens Essential Oil on Methomyl-Induced Oxidative Stress and Spatial Working Memory Impairment in Association with Histopathological Changes in the Hippocampus of Male Wistar Rats.

Authors:  Khene M'hammed Amine; Chabane Kahina; Habchi Nawel; Zaida Faiza; Giaimis Jean; Toumi Mohamed; Mameri Saâdia; Baz Ahsene
Journal:  Basic Clin Neurosci       Date:  2020-07-01
  5 in total

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