| Literature DB >> 26638921 |
Venerando Rapisarda1, Caterina Ledda1, Marcello Migliore2, Rossella Salemi3, Andrea Musumeci4, Massimo Bracci5, Andrea Marconi1, Carla Loreto6, Massimo Libra3.
Abstract
FBLN-3 has recently been proposed as a biomarker for malignant mesothelioma. A significantly increased standardized mortality rate from malignant mesothelioma has been reported in Biancavilla, Italy. Its cause has been identified in environmental exposure to fluoro-edenite. The aim of this study was to seek a correlation between plasma FBLN-3 concentration and pleural plaques in subjects exposed to fluoro-edenite and in a nonexposed control group. Pleural plaques was never detected in the control group, whereas it was found in 52% of exposed subjects. Median FBLN-3 concentrations were 12.96 and 5.29 ng/ml in the exposed and the control group, respectively (p < 0.001). FBLN-3 plasma levels exhibited a high predictive value for the presence of pleural plaques.Entities:
Keywords: Biancavilla; FBLN-3; Mt Etna; environmental; fibers; fluoro-edenite; malignant mesothelioma; occupational exposure; pleural plaques
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Year: 2015 PMID： 26638921 DOI： 10.2217/fon.15.271
Source DB: PubMed Journal: Future Oncol ISSN： 1479-6694 Impact factor: 3.404