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Literature DB >> 26638763

The Endocannabinoid Signaling System in the CNS: A Primer.

Abstract

The purpose of this chapter is to provide an introduction to the mechanisms for the regulation of endocannabinoid signaling through n class="Gene">CB1 cannabinoid receptors in the central nervous system. The processes involved in the synthesis and degradation of the two most well-studied n>n class="Chemical">endocannabinoids, 2-arachidonoylglycerol and N-arachidonylethanolamine are outlined along with information regarding the regulation of the proteins involved. Signaling mechanisms and pharmacology of the CB1 cannabinoid receptor are outlined, as is the paradigm of endocannabinoid/CB1 receptor regulation of neurotransmitter release. The reader is encouraged to appreciate the importance of the endocannabinoid/CB1 receptor signaling system in the regulation of synaptic activity in the brain.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: CB1 cannabinoid receptor; Degradation; Endocannabinoid; Synaptic plasticity; Synthesis

Mesh：

Substances：
Endocannabinoids

Year: 2015 PMID： 26638763 PMCID： PMC6813823 DOI： 10.1016/bs.irn.2015.10.001

Source DB: PubMed Journal: Int Rev Neurobiol ISSN： 0074-7742 Impact factor: 3.230

270 in total

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Journal: Obesity (Silver Spring) Date: 2014-03-11 Impact factor: 5.002

3. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.

Authors: L Hanus; S Abu-Lafi; E Fride; A Breuer; Z Vogel; D E Shalev; I Kustanovich; R Mechoulam
Journal: Proc Natl Acad Sci U S A Date: 2001-03-20 Impact factor: 11.205

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Journal: J Pharmacol Exp Ther Date: 1999-06 Impact factor: 4.030

5. Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

Authors: Dina Navia-Paldanius; Niina Aaltonen; Marko Lehtonen; Juha R Savinainen; Ulrike Taschler; Franz P W Radner; Robert Zimmermann; Jarmo T Laitinen
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Authors: Jimok Kim; Masako Isokawa; Catherine Ledent; Bradley E Alger
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Review 8. Endocannabinoid signaling and synaptic function.

Authors: Pablo E Castillo; Thomas J Younts; Andrés E Chávez; Yuki Hashimotodani
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Review 9. New players in the fatty acyl ethanolamide metabolism.

Authors: Iffat Ara Sonia Rahman; Kazuhito Tsuboi; Toru Uyama; Natsuo Ueda
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10. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis.

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36 in total

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Journal: Am J Physiol Regul Integr Comp Physiol Date: 2017-02-01 Impact factor: 3.619

Review 2. Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?

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Journal: Neuropsychopharmacology Date: 2017-06-27 Impact factor: 7.853

Review 3. High times for cannabis: Epigenetic imprint and its legacy on brain and behavior.

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Journal: Neurosci Biobehav Rev Date: 2017-05-12 Impact factor: 8.989

4. Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2.

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Journal: Methods Enzymol Date: 2017-07-17 Impact factor: 1.600

Review 5. Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis.

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Journal: Compr Physiol Date: 2016-12-06 Impact factor: 9.090

6. Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.

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Journal: Neuropsychopharmacology Date: 2017-08-17 Impact factor: 7.853