AIM: To investigate polymorphisms that are probable indicators of response variability during cancer treatment with 5-fluorouracil (rs16430, rs2279198, rs1801159 and rs17878362). MATERIALS AND METHODS: We investigated 1,038 individuals regarding allele distribution from different populations, out of which we genotyped 127 individuals from a Brazilian admixed population. Similarity analyses with parental populations were performed. Prevalence of potentially deleterious alleles was also evaluated. RESULTS: Thirty-seven percent of the population had at least three potentially deleterious alleles and 38.6% had at least one potentially deleterious allele in homozygosis. CONCLUSION: Potentially deleterious alleles are present under diverse frequencies in different populations. Therefore, genotyping prior to 5-fluorouracil administration should be recommended. Copyright
AIM: To investigate polymorphisms that are probable indicators of response variability during cancer treatment with 5-fluorouracil (rs16430, rs2279198, rs1801159 and rs17878362). MATERIALS AND METHODS: We investigated 1,038 individuals regarding allele distribution from different populations, out of which we genotyped 127 individuals from a Brazilian admixed population. Similarity analyses with parental populations were performed. Prevalence of potentially deleterious alleles was also evaluated. RESULTS: Thirty-seven percent of the population had at least three potentially deleterious alleles and 38.6% had at least one potentially deleterious allele in homozygosis. CONCLUSION: Potentially deleterious alleles are present under diverse frequencies in different populations. Therefore, genotyping prior to 5-fluorouracil administration should be recommended. Copyright
Authors: Roberta B Andrade; Giovanna C Cavalcante; Marcos A T Amador; Fabiano Cordeiro Moreira; André S Khayat; Paulo P Assumpção; Ândrea Ribeiro-Dos-Santos; Ney P C Santos; Sidney Santos Journal: Curr Issues Mol Biol Date: 2022-05-19 Impact factor: 2.976
Authors: Marcos A T Amador; Giovanna C Cavalcante; Ney P C Santos; Leonor Gusmão; João F Guerreiro; Ândrea Ribeiro-dos-Santos; Sidney Santos Journal: BMC Res Notes Date: 2016-02-16