Jin Ho Song1, Bae-Kwon Jeong1, Hoon-Sik Choi2, Hojin Jeong1, Myoung Hee Kang3, Jung Hun Kang3, Jin Pyeong Kim4, Jung Je Park4, Seung Hoon Woo4, Hong Seok Jang5, Byung Ock Choi5, Ki Mun Kang6. 1. Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea. 2. Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea. 3. Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea. 4. Department of Otorhinolaryngology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea. 5. Department of Radiation Oncology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 6. Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea jsk92@gnu.ac.kr.
Abstract
BACKGROUND: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT. RESULTS: There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT. CONCLUSION: IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities. Copyright
BACKGROUND: We compared the patterns of failure between 3-dimensional radiotherapy (3D-RT) and intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: We reviewed the medical records of 49 patients with stage III-IV HNSCC treated with concurrent chemoradiotherapy. The treatment outcome, patterns of failure, and toxicities were compared between 3D-RT and IMRT. RESULTS: There were 13 locoregional recurrences as initial failure sites. Eight recurrences were local, three were regional, and two were both local and regional. The recurrence pattern did not differ between the 3D-RT- and IMRT-treated groups, while toxicities were reduced in the IMRT-treated group. All recurrences were within the high-risk planning target volume except for one case in IMRT. CONCLUSION: IMRT did not increase the risk of locoregional recurrence neither did it change the pattern of failure in patients with stage III-IV locally advanced HNSCC, although it did reduce toxicities. Copyright
Authors: Ramez Philips; Daniel Martin; Antoine Eskander; Jeffrey Schord; Nicole Brown; Songzhu Zhao; Guy Brock; Bhavna Kumar; Ricardo Carrau; Enver Ozer; Amit Agrawal; Stephen Y Kang; James W Rocco; David Schuller; Syed Ali; Dukagjin Blakaj; Aashish Bhatt; John Grecula; Theodoros Teknos; Virginia Diavolitsis; Matthew Old Journal: Oral Oncol Date: 2018-01-20 Impact factor: 5.337