Literature DB >> 26637396

GATA3 in Breast Cancer: Tumor Suppressor or Oncogene?

Motoki Takaku1, Sara A Grimm, Paul A Wade.   

Abstract

GATA3 is a highly conserved, essential transcription factor expressed in a number of tissues, including the mammary gland. GATA3 expression is required for normal development of the mammary gland where it is estimated to be the most abundant transcription factor in luminal epithelial cells. In breast cancer, GATA3 expression is highly correlated with the luminal transcriptional program. Recent genomic analysis of human breast cancers has revealed high-frequency mutation in GATA3 in luminal tumors, suggesting "driver" function(s). Here we discuss mutation of GATA3 in breast cancer and the potential mechanism(s) by which mutation may lead to a growth advantage in cancer.

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Year:  2015        PMID： 26637396      PMCID： PMC4758516          DOI： 10.3727/105221615X14399878166113

Source DB:  PubMed          Journal:  Gene Expr        ISSN： 1052-2166


  32 in total

Review 1.  Transcriptional drivers of the T-cell lineage program.

Authors:  Ellen V Rothenberg
Journal:  Curr Opin Immunol       Date:  2012-01-19       Impact factor: 7.486

2.  DNA-binding specificities of the GATA transcription factor family.

Authors:  L J Ko; J D Engel
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272

3.  GATA3 inhibits breast cancer metastasis through the reversal of epithelial-mesenchymal transition.

Authors:  Wei Yan; Qing Jackie Cao; Richard B Arenas; Brooke Bentley; Rong Shao
Journal:  J Biol Chem       Date:  2010-02-26       Impact factor: 5.157

4.  Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3.

Authors:  Jing Zhang; Chen Chen; Xiaoxia Hou; Yayi Gao; Fang Lin; Jing Yang; Zhimei Gao; Lina Pan; Lianqin Tao; Chijun Wen; Zhengju Yao; Andy Tsun; Guochao Shi; Bin Li
Journal:  J Biol Chem       Date:  2013-02-10       Impact factor: 5.157

5.  Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome.

Authors:  Heather M Gibson; Anjali Mishra; Derek V Chan; Timothy S Hake; Pierluigi Porcu; Henry K Wong
Journal:  J Invest Dermatol       Date:  2012-09-06       Impact factor: 8.551

6.  The landscape of cancer genes and mutational processes in breast cancer.

Authors:  Philip J Stephens; Patrick S Tarpey; Helen Davies; Peter Van Loo; Chris Greenman; David C Wedge; Serena Nik-Zainal; Sancha Martin; Ignacio Varela; Graham R Bignell; Lucy R Yates; Elli Papaemmanuil; David Beare; Adam Butler; Angela Cheverton; John Gamble; Jonathan Hinton; Mingming Jia; Alagu Jayakumar; David Jones; Calli Latimer; King Wai Lau; Stuart McLaren; David J McBride; Andrew Menzies; Laura Mudie; Keiran Raine; Roland Rad; Michael Spencer Chapman; Jon Teague; Douglas Easton; Anita Langerød; Ming Ta Michael Lee; Chen-Yang Shen; Benita Tan Kiat Tee; Bernice Wong Huimin; Annegien Broeks; Ana Cristina Vargas; Gulisa Turashvili; John Martens; Aquila Fatima; Penelope Miron; Suet-Feung Chin; Gilles Thomas; Sandrine Boyault; Odette Mariani; Sunil R Lakhani; Marc van de Vijver; Laura van 't Veer; John Foekens; Christine Desmedt; Christos Sotiriou; Andrew Tutt; Carlos Caldas; Jorge S Reis-Filho; Samuel A J R Aparicio; Anne Vincent Salomon; Anne-Lise Børresen-Dale; Andrea L Richardson; Peter J Campbell; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2012-05-16       Impact factor: 49.962

7.  Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state.

Authors:  Say Li Kong; Guoliang Li; Siang Lin Loh; Wing-Kin Sung; Edison T Liu
Journal:  Mol Syst Biol       Date:  2011-08-30       Impact factor: 11.429

8.  Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover.

Authors:  Aleksandra B Adomas; Sara A Grimm; Christine Malone; Motoki Takaku; Jennifer K Sims; Paul A Wade
Journal:  BMC Cancer       Date:  2014-04-22       Impact factor: 4.430

9.  Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

Authors:  I C Ho; P Vorhees; N Marin; B K Oakley; S F Tsai; S H Orkin; J M Leiden
Journal:  EMBO J       Date:  1991-05       Impact factor: 11.598

10.  GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility.

Authors:  Vasiliki Theodorou; Rory Stark; Suraj Menon; Jason S Carroll
Journal:  Genome Res       Date:  2012-11-21       Impact factor: 9.043
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  38 in total

1.  Identification of Human Lineage-Specific Transcriptional Coregulators Enabled by a Glossary of Binding Modules and Tunable Genomic Backgrounds.

Authors:  Luca Mariani; Kathryn Weinand; Anastasia Vedenko; Luis A Barrera; Martha L Bulyk
Journal:  Cell Syst       Date:  2017-09-27       Impact factor: 10.304

2.  The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression.

Authors:  F Zhang; H Tang; Y Jiang; Z Mao
Journal:  Oncogene       Date:  2017-05-08       Impact factor: 9.867

3.  MicroRNA-455-3p mediates GATA3 tumor suppression in mammary epithelial cells by inhibiting TGF-β signaling.

Authors:  Yi Zeng; Tianyang Gao; Wei Huang; Yang Yang; Rongfang Qiu; Yongqiang Hou; Wenqian Yu; Shuai Leng; Dandan Feng; Wei Liu; Xu Teng; Hefen Yu; Yan Wang
Journal:  J Biol Chem       Date:  2019-09-06       Impact factor: 5.157

4.  Using association signal annotations to boost similarity network fusion.

Authors:  Peifeng Ruan; Ya Wang; Ronglai Shen; Shuang Wang
Journal:  Bioinformatics       Date:  2019-10-01       Impact factor: 6.937

5.  Association Between GATA3 and Histopathological and Immunohistochemical Parameters in Early-Infiltrating Breast Carcinomas.

Authors:  Priscila de Medeiros Souza; Filomena Marino Carvalho; Fernando N Aguiar; Débora Gagliato; Alfredo Carlos Simões Dornellas de Barros
Journal:  Eur J Breast Health       Date:  2022-07-01

6.  Combined Analysis of ChIP Sequencing and Gene Expression Dataset in Breast Cancer.

Authors:  Pengfei Liu; Wenhua Jiang; Shiyong Zhou; Jun Gao; Huilai Zhang
Journal:  Pathol Oncol Res       Date:  2016-09-21       Impact factor: 3.201

7.  Cancer-specific mutation of GATA3 disrupts the transcriptional regulatory network governed by Estrogen Receptor alpha, FOXA1 and GATA3.

Authors:  Motoki Takaku; Sara A Grimm; Bony De Kumar; Brian D Bennett; Paul A Wade
Journal:  Nucleic Acids Res       Date:  2020-05-21       Impact factor: 16.971

8.  Identification of crucial long non-coding RNAs and mRNAs along with related regulatory networks through microarray analysis in esophageal carcinoma.

Authors:  Yaowen Zhang; Huitao Wang; Fuyou Zhou; Anlin Hao; Ningtao Dai; Haijun Yang; Anping Zheng
Journal:  Funct Integr Genomics       Date:  2021-04-16       Impact factor: 3.410

9.  Role of GATA3 exon 6 germline mutations in breast cancer progression in Egyptian female patients.

Authors:  Iman H Ibrahim; Heba G Abdel-Aziz; Fatema Em Hassan; Hesham Sa El-Sameea
Journal:  Exp Biol Med (Maywood)       Date:  2020-09-17

10.  Expression Analysis of Long Non-Coding RNAs Related With FOXM1, GATA3, FOXA1 and ESR1 in Breast Tissues.

Authors:  Bita Hassani; Mohammad Taheri; Yazdan Asgari; Ali Zekri; Ali Sattari; Soudeh Ghafouri-Fard; Farkhondeh Pouresmaeili
Journal:  Front Oncol       Date:  2021-05-19       Impact factor: 6.244
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