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Literature DB >> 2663734

Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1.

Abstract

Changes in pharmacokinetics and pharmacodynamics which occur with aging are reviewed. In Part 1, age-related alterations in pharmacokinetics, which deals with absorption, distribution, metabolism and elimination of drugs, are summarized. Special emphasis is placed on "drug clearance" which conceptual importance for the evaluation of drug elimination has only been recently recognized. Age-related physiological alterations and their influence on major determinants for each organ clearance are discussed.

Mesh：

Year: 1989 PMID： 2663734

Source DB: PubMed Journal: Int J Clin Pharmacol Ther Toxicol ISSN： 0174-4879

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Cited

10 in total

1. Prescribing Strategies for the Frail Elderly: Patient function as an indispensable end point.

Authors: J P Sloan
Journal: Can Fam Physician Date: 1992-10 Impact factor: 3.275

Review 2. Physiological changes due to age. Pharmacodynamic changes of drug action and implications for therapy.

Authors: P P Lamy
Journal: Drugs Aging Date: 1991 Sep-Oct Impact factor: 3.923

3. Quality of drug prescribing in elderly people in nursing homes and special care units for dementia: a cross-sectional computerized pharmacy register analysis.

Authors: Jonny Olsson; Asa Bergman; Anders Carlsten; Thimothy Oké; Cecilia Bernsten; Ingrid K Schmidt; Johan Fastbom
Journal: Clin Drug Investig Date: 2010 Impact factor: 2.859

10. Number of drugs in the medication list as an indicator of prescribing quality: a validation study of polypharmacy indicators in older hip fracture patients.

Authors: Björn Belfrage; Anders Koldestam; Christina Sjöberg; Susanna M Wallerstedt
Journal: Eur J Clin Pharmacol Date: 2015-01-09 Impact factor: 2.953

10 in total

Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1.

1. Prescribing Strategies for the Frail Elderly: Patient function as an indispensable end point.

Review 2. Physiological changes due to age. Pharmacodynamic changes of drug action and implications for therapy.

3. Quality of drug prescribing in elderly people in nursing homes and special care units for dementia: a cross-sectional computerized pharmacy register analysis.

Review 4. Differential kinetics of phenytoin in elderly patients.

Review 5. Hypertension in the elderly: a Japanese perspective.

Review 6. Clinical pharmacokinetics of goserelin.

7. Pharmacokinetics of quetiapine in elderly patients with selected psychotic disorders.

8. Single-dose pharmacokinetics of rifapentine in elderly men.

9. Pharmacokinetics of chlormezanone in elderly patients.

10. Number of drugs in the medication list as an indicator of prescribing quality: a validation study of polypharmacy indicators in older hip fracture patients.