PURPOSE: The aim of this study was to evaluate choroidal thickness changes during acute attacks of familial Mediterranean fever (FMF). METHODS: Fifty patients with FMF and 50 healthy controls were included. Choroidal thickness of each participant was measured at the foveola and horizontal nasal and temporal quadrants at 500-µm intervals to 1,500 µm from the foveola using spectral-domain optical coherence tomography. White blood cell count, erythrocyte sedimentation rate (ESR) and serum levels of fibrinogen and C-reactive protein (CRP) were evaluated. The clinical findings (peritonitis, arthritis and pleuritis) were noted. RESULTS: Choroidal thickness was significantly thicker at all measurement points in FMF patients compared to healthy controls during an acute attack (p < 0.05). There were positive correlations between the choroidal thickness and ESR, fibrinogen and, particularly, CRP levels. Clinical findings did not change the choroidal thickness significantly (p > 0.05). CONCLUSIONS: Increased choroidal thickness in the acute phase of FMF is possibly related to the inflammatory edematous changes in the choroid.
PURPOSE: The aim of this study was to evaluate choroidal thickness changes during acute attacks of familial Mediterranean fever (FMF). METHODS: Fifty patients with FMF and 50 healthy controls were included. Choroidal thickness of each participant was measured at the foveola and horizontal nasal and temporal quadrants at 500-µm intervals to 1,500 µm from the foveola using spectral-domain optical coherence tomography. White blood cell count, erythrocyte sedimentation rate (ESR) and serum levels of fibrinogen and C-reactive protein (CRP) were evaluated. The clinical findings (peritonitis, arthritis and pleuritis) were noted. RESULTS: Choroidal thickness was significantly thicker at all measurement points in FMFpatients compared to healthy controls during an acute attack (p < 0.05). There were positive correlations between the choroidal thickness and ESR, fibrinogen and, particularly, CRP levels. Clinical findings did not change the choroidal thickness significantly (p > 0.05). CONCLUSIONS: Increased choroidal thickness in the acute phase of FMF is possibly related to the inflammatory edematous changes in the choroid.
Authors: Sait Alim; Mehmet Esen; Ayşe Kevser Demir; Selim Demir; Hüseyin Ortak; Alper Güneş; Tufan Alatli; Helin Deniz Demir Journal: Int Ophthalmol Date: 2017-01-21 Impact factor: 2.031
Authors: Hana A Mansour; Pinar Ç Ozdal; Sibel Kadayifcilar; Ilknur Tugal-Tutkun; Hilal Eser-Ozturk; F Nilüfer Yalçındağ; Harry Petrushkin; Errol W Chan; Soukaina Belfaiza; Remzi Karadag; Sirel Gür Güngör; Maurizio Battaglia Parodi; Ahmad M Mansour Journal: Eye (Lond) Date: 2021-11-01 Impact factor: 4.456