Sapna Vyakaranam1, Aparna Varma Bhongir1, Dakshayani Patlolla1, Rekha Chintapally2. 1. Department of Biochemistry, Mediciti Institute of Medical Sciences, Ghanpur-501401, Medchal Mandal Ranga Reddy, Telangana, India. 2. Department of Gynaecology & Obstetrics, Mediciti Institute of Medical Sciences, Ghanpur-501401, Medchal Mandal Ranga Reddy, Telangana, India.
Abstract
BACKGROUND: Hypoxia driven oxidative stress of the placenta contributes to the pathogenesis of preeclampsia. Serum Ischemia Modified Albumin (IMA) has recently emerged as an oxidative stress marker, used in diagnosis of cardiac ischemia. Aim: To determine the efficiency of serum IMA in differentiating hypertensive disorders of pregnancy (pregnancy induced hypertension, preeclampsia) from normal pregnancy. METHODS: It was a case control study. Pregnant women ≥32 weeks of gestation. Study population were included 3 groups, 19 Normotensive Pregnant (NP) women as controls, 18 pregnant women with Pregnancy Induced Hypertension (PIH) and 19 with preeclampsia (PE). Serum IMA was estimated by Enzyme Linked Immune Sorbent Assay (ELISA). Results were analyzed by student 't'test. Critical values for serum IMA were obtained by Receiver Operation Characteristics (ROC) curves. RESULTS: Serum IMA levels were significantly elevated in PE (56.84 ± 21.57 ng/ml) when compared with PIH (36.24 ± 14.51 ng/ml) and NP (35.47 ± 11.58 ng/ml) (P value <0.001). With a cutoff of 38.33 ng/ml, sensitivity and specificity for preeclampsia was 88.9% and 73.7% respectively. CONCLUSIONS: Our study demonstrated that serum IMA, an oxidative stress marker is elevated in PE & PIH. Hence serum IMA can undergo further evaluation as a marker of PE.
BACKGROUND:Hypoxia driven oxidative stress of the placenta contributes to the pathogenesis of preeclampsia. Serum Ischemia Modified Albumin (IMA) has recently emerged as an oxidative stress marker, used in diagnosis of cardiac ischemia. Aim: To determine the efficiency of serum IMA in differentiating hypertensive disorders of pregnancy (pregnancy induced hypertension, preeclampsia) from normal pregnancy. METHODS: It was a case control study. Pregnant women ≥32 weeks of gestation. Study population were included 3 groups, 19 Normotensive Pregnant (NP) womenas controls, 18 pregnant women with Pregnancy Induced Hypertension (PIH) and 19 with preeclampsia (PE). Serum IMA was estimated by Enzyme Linked Immune Sorbent Assay (ELISA). Results were analyzed by student 't'test. Critical values for serum IMA were obtained by Receiver Operation Characteristics (ROC) curves. RESULTS: Serum IMA levels were significantly elevated in PE (56.84 ± 21.57 ng/ml) when compared with PIH (36.24 ± 14.51 ng/ml) and NP (35.47 ± 11.58 ng/ml) (P value <0.001). With a cutoff of 38.33 ng/ml, sensitivity and specificity for preeclampsia was 88.9% and 73.7% respectively. CONCLUSIONS: Our study demonstrated that serum IMA, an oxidative stress marker is elevated in PE & PIH. Hence serum IMA can undergo further evaluation as a marker of PE.
Entities:
Keywords:
Early marker; Ischemia modified albumin; Preeclampsia; Pregnancy induced hypertension
Authors: Saif Anwaruddin; James L Januzzi; Aaron L Baggish; Elizabeth Lee Lewandrowski; Kent B Lewandrowski Journal: Am J Clin Pathol Date: 2005-01 Impact factor: 2.493
Authors: Rajan Sharma; David C Gaze; Denis Pellerin; Rajnikant L Mehta; Helen Gregson; Christopher P Streather; Paul O Collinson; Stephen J D Brecker Journal: Am J Kidney Dis Date: 2006-03 Impact factor: 8.860
Authors: David Bar-Or; Leonard T Rael; Raphael Bar-Or; Denetta S Slone; Charles W Mains; Nagaraja K R Rao; C Gerald Curtis Journal: Clin Chim Acta Date: 2007-10-02 Impact factor: 3.786
Authors: James P C Coverdale; Kondwani G H Katundu; Amélie I S Sobczak; Swati Arya; Claudia A Blindauer; Alan J Stewart Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2018-07-20 Impact factor: 4.006