Literature DB >> 2663528

Effect of endothelin on renal function in rats.

A López-Farré1, I Montañés, I Millás, J M López-Novoa.   

Abstract

The effect of synthetic porcine endothelin on glomerular filtration rate, renal plasma flow and electrolyte excretion was studied in rats. Endothelin, 1 nmol/kg body weight given as a bolus, induced a transient decrease in glomerular filtration rate (72%) and in renal plasma flow (76%) as well as in sodium excretion, accompanied by a sustained increase in renal vascular resistance. This dose had no sustained effect on mean arterial pressure. It is concluded that endothelin induces a marked decrease in glomerular filtration rate and renal perfusion. This peptide could play a role in the alterations in renal function observed after renal injury.

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Year:  1989        PMID： 2663528     DOI： 10.1016/0014-2999(89)90417-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

Review 1.  Role of endothelin in hypertension.

Authors:  B K Krämer; M Ackermann; S M Kohler; G A Riegger
Journal:  Clin Investig       Date:  1994-01

2.  Endothelin is an important determinant of renal function in a rat model of acute liver and renal failure.

Authors:  R Anand; D Harry; S Holt; P Milner; M Dashwood; D Goodier; M Jarmulowicz; K Moore
Journal:  Gut       Date:  2002-01       Impact factor: 23.059

3.  Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat.

Authors:  J G Filep; E Földes-Filep; A Rousseau; P Sirois; A Fournier
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

4.  Endothelin-1 in the rabbit: interactions with cyclo-oxygenase and NO-synthase products.

Authors:  M E Rogerson; H S Cairns; L D Fairbanks; J Westwick; G H Neild
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

5.  Haemodynamic and renal tubular effects of low doses of endothelin in anaesthetized rats.

Authors:  P J Harris; J Zhuo; F A Mendelsohn; S L Skinner
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

6.  Comparison of haemoconcentration induced by big endothelin-1 and endothelin-1 in mice.

Authors:  H Okumura; N Ashizawa; F Kobayashi; K Arai; R Asakura; N Ashikawa; A Matsuura
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

Review 7.  Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure.

Authors:  Navneet S Rehsia; Naranjan S Dhalla
Journal:  Heart Fail Rev       Date:  2010-01       Impact factor: 4.214

8.  Enhancement by endothelin-1 of microvascular permeability via the activation of ETA receptors.

Authors:  J G Filep; M G Sirois; E Földes-Filep; A Rousseau; G E Plante; A Fournier; M Yano; P Sirois
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

9.  A role for endothelin in the maintenance of post-ischaemic renal failure in the rat.

Authors:  A López-Farré; D Gómez-Garre; F Bernabeu; J M López-Novoa
Journal:  J Physiol       Date:  1991-12       Impact factor: 5.182

10.  Differences in regional vascular sensitivity to endothelin-1 between spontaneously hypertensive and normotensive Wistar-Kyoto rats.

Authors:  C E Wright; J R Fozard
Journal:  Br J Pharmacol       Date:  1990-05       Impact factor: 8.739
  10 in total

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