Mark Loeb1. 1. Departments of Pathology & Molecular Medicine and Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada.
Abstract
INTRODUCTION: In the Northern Hemisphere about 12/1000 people per year (on average) contract pneumonia while living in the community, with most cases caused by Streptococcus pneumoniae. Mortality ranges from about 5% to 35% depending on severity of disease, with a worse prognosis in older people, men, and people with chronic diseases. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of pneumococcal vaccine to prevent community-acquired pneumonia? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). RESULTS: At this update, searching of electronic databases retrieved 651 studies. After deduplication and removal of conference abstracts, 403 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 348 studies and the further review of 55 full publications. Of the 55 full articles evaluated, eight systematic reviews and one RCT were added at this update. In addition, one RCT was added to the Comment section. We performed a GRADE evaluation for five PICO combinations. CONCLUSIONS: In this systematic overview, we categorised the efficacy for two intervention based on information about the effectiveness and safety of conjugated vaccine and polysaccharide vaccine.
INTRODUCTION: In the Northern Hemisphere about 12/1000 people per year (on average) contract pneumonia while living in the community, with most cases caused by Streptococcus pneumoniae. Mortality ranges from about 5% to 35% depending on severity of disease, with a worse prognosis in older people, men, and people with chronic diseases. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of pneumococcal vaccine to prevent community-acquired pneumonia? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). RESULTS: At this update, searching of electronic databases retrieved 651 studies. After deduplication and removal of conference abstracts, 403 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 348 studies and the further review of 55 full publications. Of the 55 full articles evaluated, eight systematic reviews and one RCT were added at this update. In addition, one RCT was added to the Comment section. We performed a GRADE evaluation for five PICO combinations. CONCLUSIONS: In this systematic overview, we categorised the efficacy for two intervention based on information about the effectiveness and safety of conjugated vaccine and polysaccharide vaccine.
Authors: Marinos C Makris; Konstantinos A Polyzos; Michael N Mavros; Stavros Athanasiou; Petros I Rafailidis; Matthew E Falagas Journal: Drug Saf Date: 2012-01-01 Impact factor: 5.606
Authors: Marc J M Bonten; Susanne M Huijts; Marieke Bolkenbaas; Chris Webber; Scott Patterson; Samantha Gault; Cornelis H van Werkhoven; Anna M M van Deursen; Elisabeth A M Sanders; Theo J M Verheij; Michael Patton; Anne McDonough; Anita Moradoghli-Haftvani; Helen Smith; Tracey Mellelieu; Michael W Pride; Graham Crowther; Beate Schmoele-Thoma; Daniel A Scott; Kathrin U Jansen; Rita Lobatto; Bas Oosterman; Nils Visser; Esther Caspers; Andre Smorenburg; Emilio A Emini; William C Gruber; Diederick E Grobbee Journal: N Engl J Med Date: 2015-03-19 Impact factor: 91.245