Literature DB >> 26634875

An Efficient and Facile Method for the Synthesis of Benzimidazoisoquinoline Derivatives via a Multicomponent Reaction.

Wen-Li Liao1, Shi-Qiang Li1, Jun Wang1, Zhi-Yu Zhang1, Zhi-Wei Yang1, Di Xu1, Chuan Xu2,3, Hai-Tao Lan4, Zhong-Zhu Chen1, Zhi-Gang Xu1.   

Abstract

Two series of benzimidazoisoquinoline and fused benzimidazoisoquinoline-benzimidazole derivatives have been synthesized using an efficient one-pot procedure. This process involves an intramolecular nucleophilic substitution reaction and provides facile access to two series of complexes and potentially interesting biologically active scaffolds.

Entities:  

Keywords:  benzimidazoisoquinoline; benzimidazole; multicomponent reactions (MCRs); nucleophilic substitution reaction; one-pot

Mesh：

Substances：

Year:  2015        PMID： 26634875     DOI： 10.1021/acscombsci.5b00145

Source DB:  PubMed          Journal:  ACS Comb Sci        ISSN： 2156-8944            Impact factor:   3.784


  8 in total

1.  Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells.

Authors:  Liu-Jun He; Dong-Lin Yang; Shi-Qiang Li; Ya-Jun Zhang; Yan Tang; Jie Lei; Brendan Frett; Hui-Kuan Lin; Hong-Yu Li; Zhong-Zhu Chen; Zhi-Gang Xu
Journal:  Bioorg Med Chem       Date:  2018-06-12       Impact factor: 3.641

2.  Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction.

Authors:  Zhi-Gang Xu; Shi-Qiang Li; Jiang-Ping Meng; Dian-Yong Tang; Liu-Jun He; Jie Lei; Hui-Kuan Lin; Hong-Yu Li; Zhong-Zhu Chen
Journal:  Chemistry       Date:  2018-04-20       Impact factor: 5.236

Review 3.  Recent Advances in Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds.

Authors:  Arseni Borissov; Yogesh Kumar Maurya; Liliia Moshniaha; Wai-Shing Wong; Marika Żyła-Karwowska; Marcin Stępień
Journal:  Chem Rev       Date:  2021-12-01       Impact factor: 60.622

4.  Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways.

Authors:  Ya-Jun Zhang; Zhi-Gang Xu; Shi-Qiang Li; Liu-Jun He; Yan Tang; Zhong-Zhu Chen; Dong-Lin Yang
Journal:  Cancer Cell Int       Date:  2018-06-28       Impact factor: 5.722

5.  Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction.

Authors:  Maryna V Murlykina; Oleksandr V Kolomiets; Maryna M Kornet; Yana I Sakhno; Sergey M Desenko; Victoriya V Dyakonenko; Svetlana V Shishkina; Oleksandr A Brazhko; Vladimir I Musatov; Alexander V Tsygankov; Erik V Van der Eycken; Valentyn A Chebanov
Journal:  Beilstein J Org Chem       Date:  2019-06-12       Impact factor: 2.883

6.  Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction.

Authors:  Yong Li; Zheng Huang; Jia Xu; Yong Ding; Dian-Yong Tang; Jie Lei; Hong-Yu Li; Zhong-Zhu Chen; Zhi-Gang Xu
Journal:  Beilstein J Org Chem       Date:  2020-04-09       Impact factor: 2.883

7.  Facile synthesis and biological evaluation of tryptamine-piperazine-2,5-dione conjugates as anticancer agents.

Authors:  Jiang-Ping Meng; Shi-Qiang Li; Yan Tang; Zhi-Gang Xu; Zhong-Zhu Chen; Li-Xia Gao
Journal:  RSC Adv       Date:  2021-08-17       Impact factor: 4.036

8.  Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents.

Authors:  Jia Xu; Hong-Bo Tan; Ya-Jun Zhang; Dian-Yong Tang; Fenghuang Zhan; Hong-Yu Li; Zhong-Zhu Chen; Zhi-Gang Xu
Journal:  Sci Rep       Date:  2020-06-09       Impact factor: 4.379
  8 in total

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