A sanguine experience: Case Report.

A 68-year-old man presents at A&E with breathlessness but no chest pain, haemoptysis or sputum production http://ow.ly/R029n.

Case presentation

A 68-year-old man attended the Accident and Emergency department with increasing breathlessness but no chest pain, sputum production or haemoptysis. He had recently returned from holiday in Spain and his general practitioner prescribed amoxicillin for a presumed chest infection. He was a diet-controlled type 2 diabetic on treatment for hypertension. He had a 40-pack-year smoking history and had lost 4 kg in weight. Examination revealed an obese man with normal blood pressure, sinus tachycardia at 100 beats⋅min−1, with a respiratory rate of 26 breaths⋅min−1. His oxygen saturation was 96% on air. His white cell count was 11×109 cells⋅L−1 and C-reactive protein was 92 mg⋅L−1. Renal function and coagulation studies were normal.

Task 1

What does his chest radiograph (figure 1) show?

Figure 1

Chest radiograph.

A large left pleural effusion

A large left pneumothorax

Left upper lobe collapse with volume loss

Left upper lobe consolidation

Answer 1

c.Left upper lobe collapse with volume loss

The admitting medical team felt that there was a “complete whiteout” of the left hemithorax and initially treated him for suspected severe community-­acquired pneumonia with intravenous antibiotics and fluids, while arranging a respiratory opinion. Prophylactic low molecular weight ­heparin (LMWH) was also started. The respiratory team felt that an underlying malignancy may have been responsible for the radiographic appearances of left upper lobe collapse and suggested a ­computed tomography (CT) scan of the thorax. Figure 1 shows a “veil-like” opacity projected over the left lung field, a raised left hemidiaphragm with blunting of the left costophrenic angle consistent with left upper lobe collapse, volume loss and an associated pleural effusion.

Task 2

What does his CT (figure 2) show?

Figure 2

CT scans.

Left upper lobe collapse

Large contralateral mediastinal nodes

Left pleural effusion

A large mass at the left hilum

All of the above

Answer 2

e.All of the above

The CT scan showed a large left hilar mass coalescing with the left upper lobe collapse. There were associated large para-aortic, subcarinal, mediastinal and supraclavicular nodes, a single liver metastasis and a second separate mass in the right lung. Lung cancer staging was T4N3M1b.

It was interesting to note that a separate mass was present in the right lung (figure 2c). He did have metastatic disease but this might represent a synchronous primary, although by strict definition, to diagnose this, we needed to prove that the second mass was of different histology to the primary mass or that it was of the same histology but with no mediastinal or metastatic spread [1].

While awaiting a bronchoscopy, the patient coughed up ∼600 mL of fresh blood in 12 h, with worsening hypoxia. Repeat full blood count and coagulation studies were normal.

Task 3

What should form part of his immediate management?

Sit upright to improve oxygenation, large-bore intravenous cannulae, blood transfusions as required, stop LMWH

Lie on side of lesion, stop prophylactic LMWH, administration of tranexamic acid

Urgent bronchoscopy and treatment with adrenaline/saline to tumour

Palliative approach with midazolam and morphine for symptom control

Answer 3

b.Lie on side of lesion, stop prophylactic LMWH, administration of tranexamic acid

The patient was having massive haemoptysis, defined as coughing up anything between 100 mL and 600 mL of fresh blood in 24 h [2, 3].

He was seen by the on-call medical team and sat upright. Two large-bore cannulae were inserted in case of exsanguination. Sitting upright runs the risk of the blood spilling over into the normal lung. “Drowning” by filling up the bronchial tree with blood tends to occur before any true haemodynamic instability due to volume loss. As such, the mainstay of treatment in massive haem­optysis is to protect the normal lung and try to stop the bleeding [4, 5].

The respiratory team felt that a palliative approach was too premature, but it was explained to him that his prognosis was poor with limited treatment options available. He agreed to a “do not resuscitate” plan. A treatment escalation plan was agreed to ensure his treatment was limited to level 2 care. Hypoxia precluded a bronchoscopy or transfer to the local cardiothoracic centre. Bronchoscopic strategies to control pulmonary haemorrhage include balloon tamponade, iced saline lavage, administration of a topical vasoconstrictor or coagulant, laser therapy and electrocautery [5].

The patient pointed to his left hemithorax when asked which side he felt the bleeding was coming from. Anecdotal experience suggests that patients with haemoptysis can often accurately indicate the side of the bleeding lesion. He was therefore positioned on his left side and tranexamic acid was administered intravenously. A pilot study evaluating the effect of tranexamic acid and the related antifibrinolytic agent aminocaproic acid included three patients with haemoptysis due to lung cancer [6]. All three patients experienced cessation of bleeding within 1–4 days without any recurrence. Patients received 1.5 g of intravenous tranexamic acid initially, followed by 1 g three times per day for a week after cessation of bleeding. The use of tranexamic acid in bleeding has been recognised for a long time [7] and tranexamic acid may reduce both the duration and volume of bleeding, with low risk of short-term thromboembolic complications [8].

His haemoptysis and hypoxia improved over the ensuing days, and at bronchoscopy an organised clot was visualised in the left upper lobe bronchus with no endobronchial masses and a normal right bronchial tree. Left upper lobe lavage revealed no malignant cells on cytology. At endobronchial ultrasound examination, a large paratracheal node was sampled and histology demonstrated a poorly differentiated necrotic squamous cell carcinoma.

The patient’s clinical condition slowly improved until 15 days into his admission, when overnight he developed acute dyspnoea with tachycardia at 120 beats⋅min−1. Arterial blood gas sampling measured his arterial oxygen tension (PaO) at 7.0 kPa on high flow oxygen via a reservoir bag, and an arterial carbon dioxide tension (PaCO) of 5.1 kPa. A repeat chest radiograph showed no change.

Task 4

What is his alveolar–arterial oxygen tension difference (PA–aO)?

Answer 4

His PA–aO is 71.625 kPa

The PA–aO is a measure of the difference between the alveolar concentration (A) of oxygen and the arterial (a) concentration of oxygen. In room air (inspiratory oxygen fraction of 0.21) at sea level (atmospheric pressure of 760 mmHg) assuming 100% humidity in the alveoli, a simplified version of the equation is 21−((PaCO/0.8)−PaO), 0.8 being the respiratory quotient.

High flow oxygen delivers ∼85% oxygen, so 85−(5.1/0.8)−7=71.625, which is significantly raised. While his PA–aO was likely to be raised due to his cancer/effusion, such a disparity and the clinical picture points towards the possibility of a pulmonary embolus. The use of the PA–aO is a useful adjunct in diagnosis [9]. There are numerous case reports about tranexamic acid increasing the risk of pulmonary emboli [10, 11]. In this case, the patient had other significant risk factors such as disseminated malignancy and a prolonged period of immobility.

Task 5

Which of the following are appropriate next courses of action?

Discuss risk/benefit of full anticoagulation with LMWH or intravenous unfractionated heparin with patient

Urgent CT pulmonary angiogram

Stop tranexamic acid and palliation of symptoms of breathlessness and agitation

Arrange urgent radiotherapy

All of the above

Answer 5

e. All of the above

The patient understood that if left untreated, a large pulmonary embolus may prove fatal, but by treating it with anticoagulation, a major fatal haemoptysis was also more likely. He agreed to receive LMWH together with morphine for symptoms of dyspnoea and agitation. 6 h later, he had improved clinically and was able to safely lie flat briefly for a CT pulmonary angiogram. This confirmed large right-sided pulmonary emboli with associated right heart strain with reflux of contrast into the venous circulation (figure 3). The option of inferior vena cava filter insertion to prevent further embolic events was not available in our hospital, and he was too unstable to be transferred to an appropriate tertiary hospital. Over the following 2 days, urgent palliative radiotherapy to the left-sided tumour was arranged. After he had received a single fraction, further large volume haemoptysis recurred. LMWH was stopped and tranexamic acid restarted. The bleeding settled once more and he completed five fractions of radiotherapy. Slowly his oxygen saturations improved to 93% on air and he was discharged home on long-term full-dose LMWH with no recurrence of the haem­optysis.

Figure 3

CT pulmonary angiogram.

He presented 3 weeks later with progressive respiratory failure and his symptoms were palliated according to his wishes.