Hui-Min Guo1, Mei Liu1, Yu-Tao Xiang2, Jing Zhao1, Gabor S Ungvari3, Christoph U Correll4, Chee H Ng5, Helen F K Chiu6, Zhong-Ping Duan1. 1. Artificial Liver Treatment and Training Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China. 2. Faculty of Health Sciences, University of Macau, Macao, SAR, China. 3. The University of Notre Dame Australia/Marian Centre, Perth, Australia. 4. Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA. 5. Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. 6. Department of Psychiatry, Chinese University of Hong Kong, Hong Kong, SAR, China.
Abstract
PURPOSE: To determine the frequency and socio-demographic/clinical correlates of insomnia in patients with chronic hepatitis B, hepatitis B virus (HBV)-related liver failure, and cirrhosis. DESIGN AND METHODS: Up to 120 patients with HBV-related diseases and 40 matched healthy controls were recruited. Depressive and anxiety symptoms, early, middle, and late insomnia were measured. FINDINGS: The frequency of ≥1 type of insomnia was 64.2% in patients and 35.0% in controls; frequencies of early, middle, and late insomnia in patients were 39.2%, 42.5%, and 48.3%, respectively, compared to 22.5%, 10.0%, and 25.0% in controls. Urban residency was independently associated with less insomnia of any type, accounting for 22.6% of the variance. PRACTICE IMPLICATIONS: A considerable proportion of patients with HBV-related diseases suffer from insomnia that warrants more attention in clinical practice.
PURPOSE: To determine the frequency and socio-demographic/clinical correlates of insomnia in patients with chronic hepatitis B, hepatitis B virus (HBV)-related liver failure, and cirrhosis. DESIGN AND METHODS: Up to 120 patients with HBV-related diseases and 40 matched healthy controls were recruited. Depressive and anxiety symptoms, early, middle, and late insomnia were measured. FINDINGS: The frequency of ≥1 type of insomnia was 64.2% in patients and 35.0% in controls; frequencies of early, middle, and late insomnia in patients were 39.2%, 42.5%, and 48.3%, respectively, compared to 22.5%, 10.0%, and 25.0% in controls. Urban residency was independently associated with less insomnia of any type, accounting for 22.6% of the variance. PRACTICE IMPLICATIONS: A considerable proportion of patients with HBV-related diseases suffer from insomnia that warrants more attention in clinical practice.