UNLABELLED: INDRODUCTION: Leptospirosis is a frequent cause of febrile illness around the world, particularly in tropical and subtropical areas such as Perú. OBJECTIVE: To estimate the frequency and socio-demographic characteristics associated with leptospirosis in febrile patients in northern Perú. MATERIALS AND METHODS: A cross sectional study was conducted from January to December 2014 in 143 fever cases admitted to the Hospital Regional Lambayeque, Perú. Structured for socio-demographic information and sanitation questionnaire was used. Serum samples were examined to quantitatively determine the presence of IgM antibodies to leptospira using ELISA IgM. RESULTS: The frequency was 26.6% (95% CI 19.3 to 33.8) and independently associated features were: be between 20-54 years (OR: 3.36, 95% CI 1.17 to 9, 64), work in agriculture-livestock (OR: 6.15, 95% CI 1.99 to 19.05),contact with animals (OR: 4,13, IC 95%: 1,76-9,65) and consumption of unsafe water(OR: 3,33, IC 95%: 1,49-7,43). CONCLUSIONS: This study reveals a high frequency of leptospirosis among febrile patients from northern Perú. These results indicate the need to investigate routinely leptospirosis in febrile patients, especially those exhibiting risk characteristics.
UNLABELLED: INDRODUCTION: Leptospirosis is a frequent cause of febrile illness around the world, particularly in tropical and subtropical areas such as Perú. OBJECTIVE: To estimate the frequency and socio-demographic characteristics associated with leptospirosis in febrile patients in northern Perú. MATERIALS AND METHODS: A cross sectional study was conducted from January to December 2014 in 143 fever cases admitted to the Hospital Regional Lambayeque, Perú. Structured for socio-demographic information and sanitation questionnaire was used. Serum samples were examined to quantitatively determine the presence of IgM antibodies to leptospira using ELISA IgM. RESULTS: The frequency was 26.6% (95% CI 19.3 to 33.8) and independently associated features were: be between 20-54 years (OR: 3.36, 95% CI 1.17 to 9, 64), work in agriculture-livestock (OR: 6.15, 95% CI 1.99 to 19.05),contact with animals (OR: 4,13, IC 95%: 1,76-9,65) and consumption of unsafe water(OR: 3,33, IC 95%: 1,49-7,43). CONCLUSIONS: This study reveals a high frequency of leptospirosis among febrile patients from northern Perú. These results indicate the need to investigate routinely leptospirosis in febrile patients, especially those exhibiting risk characteristics.
Authors: Valerie Cortez; Enrique Canal; J Catherine Dupont-Turkowsky; Tatiana Quevedo; Christian Albujar; Ti-Cheng Chang; Gabriela Salmon-Mulanovich; Maria C Guezala-Villavicencio; Mark P Simons; Elisa Margolis; Stacey Schultz-Cherry; Víctor Pacheco; Daniel G Bausch Journal: PLoS One Date: 2018-10-09 Impact factor: 3.240