Anca Lădaru1,2, Paul Bălănescu3,4, Mihaela Stan1,2, Ioana Codreanu1,2, Ioana Alina Anca1,2. 1. a University of Medicine and Pharmacy "Carol Davila" , Pediatrics Chair , Bucharest , Romania . 2. b Institute for Mother and Child Care "Alfred Rusescu" , Bucharest , Romania . 3. c Department of Clinical Immunology , CDPC Colentina Clinical Hospital , Bucharest , Romania , and. 4. d Clinical Research Unit RECIF (Réseau D' Epidémiologie Clinique International Francophone) , Bucharest , Romania.
Abstract
CONTEXT: Non-alcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in the liver which is accompanied by a series of metabolic deregulations. There are sustained research efforts focusing upon biomarker discovery for NAFLD diagnosis and its prognosis in order investigate and follow-up patients as minimally invasive as possible. OBJECTIVE: The objective of this study is to critically review proteomic studies that used mass spectrometry techniques and summarize relevant proteomic NAFLD candidate biomarkers. METHODS: Medline and Embase databases were searched from inception to December 2014. RESULTS: A final number of 22 records were included that identified 251 candidate proteomic biomarkers. Thirty-three biomarkers were confirmed - 14 were found in liver samples, 21 in serum samples, and two from both serum and liver samples. CONCLUSION: Some of the biomarkers identified have already been extensively studied regarding their diagnostic and prognostic capacity. However, there are also more potential biomarkers that still need to be addressed in future studies.
CONTEXT: Non-alcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in the liver which is accompanied by a series of metabolic deregulations. There are sustained research efforts focusing upon biomarker discovery for NAFLD diagnosis and its prognosis in order investigate and follow-up patients as minimally invasive as possible. OBJECTIVE: The objective of this study is to critically review proteomic studies that used mass spectrometry techniques and summarize relevant proteomic NAFLD candidate biomarkers. METHODS: Medline and Embase databases were searched from inception to December 2014. RESULTS: A final number of 22 records were included that identified 251 candidate proteomic biomarkers. Thirty-three biomarkers were confirmed - 14 were found in liver samples, 21 in serum samples, and two from both serum and liver samples. CONCLUSION: Some of the biomarkers identified have already been extensively studied regarding their diagnostic and prognostic capacity. However, there are also more potential biomarkers that still need to be addressed in future studies.
Authors: Prahlad K Rao; Kate Merath; Eugene Drigalenko; Avinash Y L Jadhav; Richard A Komorowski; Matthew I Goldblatt; Anand Rohatgi; Mark A Sarzynski; Samer Gawrieh; Michael Olivier Journal: Clin Proteomics Date: 2018-03-06 Impact factor: 3.988
Authors: G Craig Wood; Xin Chu; George Argyropoulos; Peter Benotti; David Rolston; Tooraj Mirshahi; Anthony Petrick; John Gabrielson; David J Carey; Johanna K DiStefano; Christopher D Still; Glenn S Gerhard Journal: Sci Rep Date: 2017-03-07 Impact factor: 4.379