Literature DB >> 26631537

Expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma tissues and clinical significance.

Bin Yu1, Hongzhou Cai1, Zicheng Xu1, Ting Xu1, Qing Zou1, Min Gu2.   

Abstract

We aimed to detect the expressions of stem cell transcription factors Nanog and Oct4 in renal cell carcinoma (RCC) tissues. Nanog and Oct4 mRNA expressions in RCC tissues significantly exceeded those in paracancerous tissues (p < 0.01 and p < 0.05), being positively correlated with histological grade (p < 0.01 and p < 0.05) and TNM stage (p < 0.05). With increasing TNM stage (p < 0.01) and lymphatic metastasis (p < 0.05), the positive expression rate of Nanog protein increased. RCC patients with low Nanog and Oct4 expressions in tumor tissues had significantly higher survival rates (p < 0.05). High Nanog and Oct4 expressions may be potential therapeutic targets.

Entities:  

Keywords:  Expression; gene; renal cell carcinoma; transcription

Mesh：

Substances：

Year:  2015        PMID： 26631537     DOI： 10.3109/21691401.2015.1105238

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  10 in total

Review 1.  NANOG expression in human development and cancerogenesis.

Authors:  Gašper Grubelnik; Emanuela Boštjančič; Ana Pavlič; Marina Kos; Nina Zidar
Journal:  Exp Biol Med (Maywood)       Date:  2020-02-10

2.  Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis.

Authors:  Axel R Göhring; Stefanie Reuter; Joachim H Clement; Xinlai Cheng; Jannick Theobald; Stefan Wölfl; Ralf Mrowka
Journal:  PLoS One       Date:  2017-04-20       Impact factor: 3.240

3.  OCT4, SOX2, and NANOG positive expression correlates with poor differentiation, advanced disease stages, and worse overall survival in HER2+ breast cancer patients.

Authors:  Fan Yang; Jiaming Zhang; Hua Yang
Journal:  Onco Targets Ther       Date:  2018-11-06       Impact factor: 4.147

4.  Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma - a retrospective study using TCGA database.

Authors:  Jingcheng Zhou; Jiangyi Wang; Baoan Hong; Kaifang Ma; Haibiao Xie; Lei Li; Kenan Zhang; Bowen Zhou; Lin Cai; Kan Gong
Journal:  Aging (Albany NY)       Date:  2019-03-15       Impact factor: 5.682

5.  SOX2 and Bcl-2 as a Novel Prognostic Value in Hepatocellular Carcinoma Progression.

Authors:  Zahra Hosseini-Khah; Mohammad Reza Babaei; Mohsen Tehrani; Magali Cucchiarini; Henning Madry; Abolghasem Ajami; Nasser Rakhshani; Alireza Rafiei; Behrooz Nikbin
Journal:  Curr Oncol       Date:  2021-08-09       Impact factor: 3.677

6.  Clinical significance of cytokeratin 19 and OCT4 as survival markers in non-metastatic and metastatic breast cancer patients.

Authors:  Lobna A Abdelaziz; Huda F Ebian; Ola A Harb; Yousef Nosery; Heba F Taha; Nashwa Nawar
Journal:  Contemp Oncol (Pozn)       Date:  2022-03-30

7.  Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer.

Authors:  Liuping You; Xin Guo; Yuenan Huang
Journal:  Yonsei Med J       Date:  2018-01       Impact factor: 2.759

8.  Co-expression of Cancer Stem Cell Markers OCT4 and NANOG Predicts Poor Prognosis in Renal Cell Carcinomas.

Authors:  Arezoo Rasti; Mitra Mehrazma; Zahra Madjd; Maryam Abolhasani; Leili Saeednejad Zanjani; Mojgan Asgari
Journal:  Sci Rep       Date:  2018-08-06       Impact factor: 4.379

9.  AC010973.2 promotes cell proliferation and is one of six stemness-related genes that predict overall survival of renal clear cell carcinoma.

Authors:  Yingqing Liu; Jiawei Wang; Lin Li; Haibo Qin; Yuang Wei; Xu Zhang; Xiaohan Ren; Wei Ding; Xudong Shen; Guangyao Li; Zhongwen Lu; Dong Zhang; Chao Qin; Lingsong Tao; Xinglin Chen
Journal:  Sci Rep       Date:  2022-03-11       Impact factor: 4.379

10.  Prognostic value of octamer binding transcription factor 4 for patients with solid tumors: A meta-analysis.

Authors:  Xiaoyan Zhao; Hui Lu; Yan Sun; Li Liu; Huafang Wang
Journal:  Medicine (Baltimore)       Date:  2020-10-16       Impact factor: 1.817
  10 in total

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