Mehmet Enes Coşkun1, Mehmet Kervancıoğlu2, Serdar Öztuzcu3, Fatma Yılmaz Coşkun4, Sercan Ergün3, Osman Başpınar2, Metin Kılınç1, Levent Temel5, Mehmet Yavuz Coşkun1. 1. a Department of Pediatrics , University of Gaziantep , Gaziantep , Turkey . 2. b Department of Pediatrics , Pediatric Cardiology Division, University of Gaziantep , Gaziantep , Turkey . 3. c Department of Medical Genetics , and. 4. d Department of Cardiology , University of Gaziantep , Gaziantep , Turkey , and. 5. e Department of Pediatrics , Division of Pediatric Intensive Care, İstanbul University , İstanbul , Turkey.
Abstract
CONTEXT: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes. OBJECTIVE: We aimed to determine miRNA expression levels in plasma of children with DCM. MATERIALS AND METHODS: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children. RESULTS: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients. DISCUSSION: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.
CONTEXT: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes. OBJECTIVE: We aimed to determine miRNA expression levels in plasma of children with DCM. MATERIALS AND METHODS: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children. RESULTS: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCMpatients. DISCUSSION: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.
Authors: Rocío Toro; Sara Blasco-Turrión; Francisco José Morales-Ponce; Pablo Gonzalez; Pablo Martínez-Camblor; Amador López-Granados; Ramon Brugada; Oscar Campuzano; Alexandra Pérez-Serra; Felix Rosa Longobardo; Alipio Mangas; Vicenta Llorente-Cortes; David de Gonzalo-Calvo Journal: J Mol Med (Berl) Date: 2018-07-14 Impact factor: 4.599