Alessandra Giuliani1, Adrian Manescu, Sara Mohammadi, Serena Mazzoni, Adriano Piattelli, Francesco Mangano, Giovanna Iezzi, Carlo Mangano. 1. *Researcher, Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche, Sezione di Biochimica, Biologia e Fisica, Università Politecnica delle Marche, Ancona, Italy. †Research Fellow, Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche, Sezione di Biochimica, Biologia e Fisica, Università Politecnica delle Marche, Ancona, Italy. ‡Research Fellow, Elettra Sincrotrone Trieste S.C.p.A., Trieste, Italy; The Abdus Salam International Centre for Theoretical Physics, Trieste, Italy; and LAC1 USC Medical Center, Los Angeles, CA. §Professor of Oral Pathology and Medicine, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy. ¶Private Practice, Gravedona (Como), Italy. ‖Researcher, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy. #Private Practice, Gravedona (Como), Italy; and Visiting Professor of University of Chieti-Pescara, Department of Medical, Oral and Biotechnological Sciences, Chieti, Italy.
Abstract
INTRODUCTION: Successful bone regeneration using both granules and blocks of biphasic calcium phosphate materials has been reported in the recent literature, in some clinical applications for maxillary sinus elevation, but the long-term kinetics of bone regeneration has still not been fully investigated. MATERIALS AND METHODS: Twenty-four bilateral sinus augmentation procedures were performed and grafted with hydroxyapatite/β-tricalcium phosphate 30/70, 12 with granules and 12 with blocks. The samples were retrieved at different time points and were evaluated for bone regeneration, graft resorption, neovascularization, and morphometric parameters by computed microtomography and histology. RESULTS: A large amount of newly formed bone was detected in the retrieved specimens, together with a good rate of biomaterial resorption and the formation of a homogeneous and rich net of new vessels. The morphometric values were comparable at 5/6 months from grafting but, 9 months after grafting, revealed that the block-based specimens mimicked slightly better than granule-based samples the healthy native bone of the maxillary site. CONCLUSION: The scaffold morphology was confirmed to influence the long-term kinetics of bone regeneration.
INTRODUCTION: Successful bone regeneration using both granules and blocks of biphasic calcium phosphate materials has been reported in the recent literature, in some clinical applications for maxillary sinus elevation, but the long-term kinetics of bone regeneration has still not been fully investigated. MATERIALS AND METHODS: Twenty-four bilateral sinus augmentation procedures were performed and grafted with hydroxyapatite/β-tricalcium phosphate 30/70, 12 with granules and 12 with blocks. The samples were retrieved at different time points and were evaluated for bone regeneration, graft resorption, neovascularization, and morphometric parameters by computed microtomography and histology. RESULTS: A large amount of newly formed bone was detected in the retrieved specimens, together with a good rate of biomaterial resorption and the formation of a homogeneous and rich net of new vessels. The morphometric values were comparable at 5/6 months from grafting but, 9 months after grafting, revealed that the block-based specimens mimicked slightly better than granule-based samples the healthy native bone of the maxillary site. CONCLUSION: The scaffold morphology was confirmed to influence the long-term kinetics of bone regeneration.
Authors: Margherita Tumedei; Eitan Mijiritsky; Carlos Fernando Mourão; Adriano Piattelli; Marco Degidi; Carlo Mangano; Giovanna Iezzi Journal: Int J Environ Res Public Health Date: 2022-06-28 Impact factor: 4.614
Authors: Fabrizia Luongo; Francesco Guido Mangano; Aldo Macchi; Giuseppe Luongo; Carlo Mangano Journal: Biomed Res Int Date: 2016-12-14 Impact factor: 3.411