| Literature DB >> 26629857 |
Chunhua Ma1, Jiangying Cao2, Xuewu Liang2, Yongxue Huang2, Ping Wu3, Yingxia Li3, Wenfang Xu2, Yingjie Zhang4.
Abstract
Aminopeptidase N (APN/CD13) over-expressed on tumor cells and tumor microenvironment, plays critical roles in tumor invasion, metastasis and angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 7a had the most potent inhibitory activity against APN with the IC50 value of 20 nM, which could be used for further anticancer agent research.Entities:
Keywords: Aminopeptidase N; Inhibitors; Leucine ureido derivatives; Synthesis
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Year: 2015 PMID： 26629857 DOI： 10.1016/j.ejmech.2015.11.021
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514