OBJECTIVES: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. METHODS: This case-control study was carried out between May 2013 and November 2014 at the Era's Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m(2)) or high (≥25 kg/m(2)) BMI. The third group consisted of 125 age-, gender- and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. RESULTS: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. CONCLUSION: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.
OBJECTIVES: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. METHODS: This case-control study was carried out between May 2013 and November 2014 at the Era's Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m(2)) or high (≥25 kg/m(2)) BMI. The third group consisted of 125 age-, gender- and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. RESULTS: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. CONCLUSION:ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.
Entities:
Keywords:
Angiotensin Converting Enzyme; Body Mass Index; Genetic Polymorphisms; Glutathione Transferase; Hypertension; India; Obesity
Authors: M Ruano; V Silvestre; R Castro; M C G García-Lescún; A Rodríguez; A Marco; G García-Blanch Journal: Obes Surg Date: 2005-05 Impact factor: 4.129
Authors: F Massiéra; M Bloch-Faure; D Ceiler; K Murakami; A Fukamizu; J M Gasc; A Quignard-Boulange; R Negrel; G Ailhaud; J Seydoux; P Meneton; M Teboul Journal: FASEB J Date: 2001-10-15 Impact factor: 5.191
Authors: A H Danser; M A Schalekamp; W A Bax; A M van den Brink; P R Saxena; G A Riegger; H Schunkert Journal: Circulation Date: 1995-09-15 Impact factor: 29.690
Authors: Joey C Eisenmann; Mark A Sarzynski; Kim Glenn; Max Rothschild; Kate A Heelan Journal: Cardiovasc Diabetol Date: 2009-03-16 Impact factor: 9.951
Authors: Catherine Duggan; Rachel Ballard-Barbash; Richard N Baumgartner; Kathy B Baumgartner; Leslie Bernstein; Anne McTiernan Journal: Springerplus Date: 2013-09-11
Authors: Waseem Khalid; Muhammad Sajid Arshad; Muhammad Modassar Ali Nawaz Ranjha; Maria Barbara Różańska; Shafeeqa Irfan; Bakhtawar Shafique; Muhammad Abdul Rahim; Muhammad Zubair Khalid; Gholamreza Abdi; Przemysław Łukasz Kowalczewski Journal: Open Life Sci Date: 2022-09-08 Impact factor: 1.311