Liqun Fang1, Wen Li2, Wenjie Zhang1, Yanan Wang1, Songbin Fu1. 1. Department of Neurology, Fourth Affiliated Hospital, Haerbin, Medical University Haerbin 150001, China. 2. Department of Neurosurgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Abstract
BACKGROUND: Researches of the relationships between dietary whole grains intake and risk of stroke have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence from observed studies regarding the association between whole grain intake and stroke risk. METHODS: Pertinent studies were identified by searching Web of Knowledge and PubMed up to May 2015. Random-effect model was used to combine the relative risk (RR) with the corresponding 95% confidence intervals (CI). Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Six prospective studies involving 1635 stroke cases and 247487 participants were included in this meta-analysis. Pooled results suggested that highest category of whole grain intake versus lowest category was significantly associated with reduced the risk of stroke [summary RR = 0.86, 95% CI = 0.73-0.99, I2 = 0.0%]. Inverse associations were also found in the America population [summary RR = 0.81, 95% CI = 0.67-0.98, I(2) = 0.0%] and subgroup analysis of females [summary RR = 0.78, 95% CI = 0.63-0.97, I(2) = 0.0%]. No publication bias was found. CONCLUSION: Our analysis indicated that higher whole grain intake has a protective effect on stroke.
BACKGROUND: Researches of the relationships between dietary whole grains intake and risk of stroke have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence from observed studies regarding the association between whole grain intake and stroke risk. METHODS: Pertinent studies were identified by searching Web of Knowledge and PubMed up to May 2015. Random-effect model was used to combine the relative risk (RR) with the corresponding 95% confidence intervals (CI). Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Six prospective studies involving 1635 stroke cases and 247487 participants were included in this meta-analysis. Pooled results suggested that highest category of whole grain intake versus lowest category was significantly associated with reduced the risk of stroke [summary RR = 0.86, 95% CI = 0.73-0.99, I2 = 0.0%]. Inverse associations were also found in the America population [summary RR = 0.81, 95% CI = 0.67-0.98, I(2) = 0.0%] and subgroup analysis of females [summary RR = 0.78, 95% CI = 0.63-0.97, I(2) = 0.0%]. No publication bias was found. CONCLUSION: Our analysis indicated that higher whole grain intake has a protective effect on stroke.
Authors: Larry B Goldstein; Cheryl D Bushnell; Robert J Adams; Lawrence J Appel; Lynne T Braun; Seemant Chaturvedi; Mark A Creager; Antonio Culebras; Robert H Eckel; Robert G Hart; Judith A Hinchey; Virginia J Howard; Edward C Jauch; Steven R Levine; James F Meschia; Wesley S Moore; J V Ian Nixon; Thomas A Pearson Journal: Stroke Date: 2010-12-02 Impact factor: 7.914
Authors: Oliver W Meldrum; Gleb E Yakubov; Ghanendra Gartaula; Michael A McGuckin; Michael J Gidley Journal: Sci Rep Date: 2017-11-17 Impact factor: 4.379