Guo-Zheng Xu1, Ying Liu2, Yi Zhang3, Jing Yu3, Bo Diao1. 1. Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Hubei Key Laboratory of Central Nervous System Tumor and Intervention Wuhan 430070, China. 2. Department of Clinical Laboratory, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China. 3. Department of Clinical Experiment, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
Abstract
OBJECTIVE: We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population. METHOD: Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2 rs2071559 genotyping. RESULTS: C allele of VEGFR2 rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2 rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018). CONCLUSION: CC genotypes of VEGFR2 rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2 rs2071559 polymorphism in glioma susceptibility remains to be further clarified.
OBJECTIVE: We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population. METHOD: Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2rs2071559 genotyping. RESULTS: C allele of VEGFR2rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018). CONCLUSION: CC genotypes of VEGFR2rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2rs2071559 polymorphism in glioma susceptibility remains to be further clarified.
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