Qian Han1, Zunhua Shu2, Xuemei Liang1, Rui Mi3, Lei Yang4, Peng Li5. 1. Department of Internal Neurology, Tianjin 4th Central Hospital Tianjin 300140, China. 2. Department of Medical Affairs, Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021, China. 3. College of Humanities, Kunming Medical University China. 4. Department of Neurosurgery , Kunming Children's Hospital Kunming 650030, China. 5. Medical Faculty of Kunming University of Science and Technology Kunming 650000, China.
Abstract
OBJECTIVE: Previous study suggested adiponectin receptor 2 (ADIPOR2) genetic polymorphisms were associated with the risk of ischemic stroke. However, the relation between adiponectin receptor 1 (ADIPOR1) gene polymorphism and stroke remains unclear. METHODS: In the present study, we utilized the polymerase chain reaction-sequencing method to detect rs2275737 and s1342387 genotypes of ADIPOR1 gene in 300 cases of ischemic stroke patients and 300 age- and sex- matched healthy controls. RESULTS: For rs2275737, we found A allele carriers have increased risk to ischemic stroke (OR=2.570, 95% CI: 1.999-3.305); also, we found rs1342387 A allele was associated with the risk for stroke (OR=1.351, 95% CI: 1.074-1.699). After adjusted for confounders such as hypertension, diabetes, and smoking, we found the association remains significant. CONCLUSION: ADIPOR1 genetic polymorphism may increase the risk of ischemic stroke.
OBJECTIVE: Previous study suggested adiponectin receptor 2 (ADIPOR2) genetic polymorphisms were associated with the risk of ischemic stroke. However, the relation between adiponectin receptor 1 (ADIPOR1) gene polymorphism and stroke remains unclear. METHODS: In the present study, we utilized the polymerase chain reaction-sequencing method to detect rs2275737 and s1342387 genotypes of ADIPOR1 gene in 300 cases of ischemic strokepatients and 300 age- and sex- matched healthy controls. RESULTS: For rs2275737, we found A allele carriers have increased risk to ischemic stroke (OR=2.570, 95% CI: 1.999-3.305); also, we found rs1342387 A allele was associated with the risk for stroke (OR=1.351, 95% CI: 1.074-1.699). After adjusted for confounders such as hypertension, diabetes, and smoking, we found the association remains significant. CONCLUSION:ADIPOR1 genetic polymorphism may increase the risk of ischemic stroke.
Entities:
Keywords:
Ischemic stroke; adiponectin receptor 1 gene; single nucleotide polymorphisms
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