Shi-Ming Zhou1, Wei Zhao2, Tao Lin2, Sheng-Tian Zhao3, Hong-Wei Wang3. 1. Department of Renal Transplantation, The Second Hospital of Shandong University Jinan 250000, China ; Department of Urinary Surgery, Liaocheng People's Hospital Liaocheng 252000, Shandong Province, China. 2. Department of Urinary Surgery, Liaocheng People's Hospital Liaocheng 252000, Shandong Province, China. 3. Department of Renal Transplantation, The Second Hospital of Shandong University Jinan 250000, China.
Abstract
OBJECTIVES: To study the significance of Cystatin C (Cys C) in early detection of the graft function after renal transplantation. MATERIAL: The concentrations of Cys C, Blood urea nitrogen (BUN), Serum creatinine (SCr), and glomerular filtration rate (GFR) were measured. According to the results of the post-transplantation GFR; Seventy renal post-transplanted patients were assigned into 3 groups: group A (31 cases with the normal range of the renal function, GFR≥90 ml/min/1.73 m(2)), group B (27 cases with Scr<133 μmol/L and 60<GFR<90 ml/min/1.73 m(2)), and group C (12 cases with Scr≥133 μmol/L and 60<Ccr<90 ml/min/1.73 m(2)). Meanwhile, 60 cases with normal renal function were applied as control group. RESULTS: The Cys C concentration in group B (1.37±0.14) was significantly higher than it in group A (0.96±0.10) (P<0.01). The SCr and the Cys C demonstrated linear correlations with the GFR in all groups of A, B and C. The correlation coefficients (r) in each group were -0.7272 and -0.7439, -0.7072 and -0.7543, -0.7430 and -0.7669; respectively. CONCLUSIONS: Compared with Scr, Cys C has better correlations with GFR when the graft function was normal or renal function was slightly impaired. Cys C could be used in the early detection of renal function impairment after transplantation.
OBJECTIVES: To study the significance of Cystatin C (Cys C) in early detection of the graft function after renal transplantation. MATERIAL: The concentrations of Cys C, Blood ureanitrogen (BUN), Serum creatinine (SCr), and glomerular filtration rate (GFR) were measured. According to the results of the post-transplantation GFR; Seventy renal post-transplanted patients were assigned into 3 groups: group A (31 cases with the normal range of the renal function, GFR≥90 ml/min/1.73 m(2)), group B (27 cases with Scr<133 μmol/L and 60<GFR<90 ml/min/1.73 m(2)), and group C (12 cases with Scr≥133 μmol/L and 60<Ccr<90 ml/min/1.73 m(2)). Meanwhile, 60 cases with normal renal function were applied as control group. RESULTS: The Cys C concentration in group B (1.37±0.14) was significantly higher than it in group A (0.96±0.10) (P<0.01). The SCr and the Cys C demonstrated linear correlations with the GFR in all groups of A, B and C. The correlation coefficients (r) in each group were -0.7272 and -0.7439, -0.7072 and -0.7543, -0.7430 and -0.7669; respectively. CONCLUSIONS: Compared with Scr, Cys C has better correlations with GFR when the graft function was normal or renal function was slightly impaired. Cys C could be used in the early detection of renal function impairment after transplantation.
Authors: E Paskalev; L Lambreva; P Simeonov; N Koicheva; B Beleva; M Genova; R Marcovska; A Nashkov Journal: Clin Chim Acta Date: 2001-08-01 Impact factor: 3.786