York Kiat Tan1, John C Allen1, Weng Kit Lye1, Philip G Conaghan1, Maria Antonietta D'Agostino1, Li-Ching Chew1, Julian Thumboo1. 1. From the Department of Rheumatology and Immunology, Singapore General Hospital; Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; Department of Rheumatology, Assistance Publique - Hôpitaux de Paris (APHP), Hôpital Ambroise Paré, Boulogne-Billancourt; Institut national de la santé et de la recherche médicale (INSERM) U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.Y.K. Tan, MBBS, MMED, MRCP, Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J.C. Allen Jr, PhD, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; W.K. Lye, MSc, Office of Clinical Sciences, Centre for Quantitative Medicine, Duke-NUS Graduate Medical School Singapore; P.G. Conaghan, MBBS, PhD, FRACP, FRCP, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; M.A. D'Agostino, MD, PhD, Professor of Rheumatology, APHP, Department of Rheumatology, Hôpital Ambroise Paré, and INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université de Versailles St.-Quentin-en-Yvelines; L.C. Chew, BMED, SCI, BMBS, MRCP, FAMS, Senior Consultant, Department of Rheumatology and Immunology, Singapore General Hospital, and Adjunct Assistant Professor, Duke-NUS Graduate Medical School, and Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore; J. Thumboo, MBBS, MMED, MRCP, FAMS, FRCP, Vice Chair for Research
Abstract
OBJECTIVE: A pilot study testing novel ultrasound (US) joint-selection methods in rheumatoid arthritis. METHODS: Responsiveness of novel [individualized US (IUS) and individualized composite US (ICUS)] methods were compared with existing US methods and the Disease Activity Score at 28 joints (DAS28) for 12 patients followed for 3 months. IUS selected up to 7 and 12 most ultrasonographically inflamed joints, while ICUS additionally incorporated clinically symptomatic joints. RESULTS: The existing, IUS, and ICUS methods' standardized response means were -0.39, -1.08, and -1.11, respectively, for 7 joints; -0.49, -1.00, and -1.16, respectively, for 12 joints; and -0.94 for DAS28. CONCLUSION: Novel methods effectively demonstrate inflammatory improvement when compared with existing methods and DAS28.
OBJECTIVE: A pilot study testing novel ultrasound (US) joint-selection methods in rheumatoid arthritis. METHODS: Responsiveness of novel [individualized US (IUS) and individualized composite US (ICUS)] methods were compared with existing US methods and the Disease Activity Score at 28 joints (DAS28) for 12 patients followed for 3 months. IUS selected up to 7 and 12 most ultrasonographically inflamed joints, while ICUS additionally incorporated clinically symptomatic joints. RESULTS: The existing, IUS, and ICUS methods' standardized response means were -0.39, -1.08, and -1.11, respectively, for 7 joints; -0.49, -1.00, and -1.16, respectively, for 12 joints; and -0.94 for DAS28. CONCLUSION: Novel methods effectively demonstrate inflammatory improvement when compared with existing methods and DAS28.
Authors: York Kiat Tan; John C Allen; Weng Kit Lye; Philip G Conaghan; Li-Ching Chew; Julian Thumboo Journal: Clin Rheumatol Date: 2016-10-03 Impact factor: 2.980
Authors: Daniel Kuo; Nicolette T Morris; Gurjit S Kaeley; Ami Ben-Artzi; Jenny Brook; David A Elashoff; Veena K Ranganath Journal: Clin Rheumatol Date: 2020-08-15 Impact factor: 2.980