Literature DB >> 2662578

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts.

A de Ronde1, C J Sol, A van Strien, J ter Schegget, J van der Noordaa.   

Abstract

The morphological transformation of human fibroblasts as measured in an assay for dense focus formation required, besides the SV40 large T antigen, an intact SV40 small t antigen. Using a G418-resistant colony formation assay it also was found that expression of the SV40 large T antigen only is not sufficient for the morphological transformation of human fibroblasts. Therefore it is concluded that the SV40 small t antigen is essential for the morphological transformation of human fibroblasts.

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Year:  1989        PMID： 2662578     DOI： 10.1016/0042-6822(89)90534-5

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  13 in total

1.  A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays.

Authors:  A Porrás; J Bennett; A Howe; K Tokos; N Bouck; B Henglein; S Sathyamangalam; B Thimmapaya; K Rundell
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

2.  The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.

Authors:  A Srinivasan; K W Peden; J M Pipas
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

3.  Enumeration of the simian virus 40 early region elements necessary for human cell transformation.

Authors:  William C Hahn; Scott K Dessain; Mary W Brooks; Jessie E King; Brian Elenbaas; David M Sabatini; James A DeCaprio; Robert A Weinberg
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

4.  Overexpression of simian virus 40 small-T antigen blocks centrosome function and mitotic progression in human fibroblasts.

Authors:  S Gaillard; K M Fahrbach; R Parkati; K Rundell
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

5.  Dissociation of retinoblastoma gene protein hyperphosphorylation and commitment to enter S phase.

Authors:  V V Ogryzko; T H Hirai; C E Shih; B H Howard
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

6.  Establishment of transformed swine fibroblast cell lines using SV40 large T antigen.

Authors:  C S Choi; M P Murtaugh; T W Molitor
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

7.  Induction of cyclin D1 by simian virus 40 small tumor antigen.

Authors:  G Watanabe; A Howe; R J Lee; C Albanese; I W Shu; A N Karnezis; L Zon; J Kyriakis; K Rundell; R G Pestell
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-12       Impact factor: 11.205

8.  Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen.

Authors:  Ying-Hui Zhang; Klaas Kooistra; Alexandra Pietersen; Jennifer L Rohn; Mathieu H M Noteborn
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

9.  Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products.

Authors:  P Yaciuk; M C Carter; J M Pipas; E Moran
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

10.  Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen.

Authors:  W B Wang; I Bikel; E Marsilio; D Newsome; D M Livingston
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103
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