Literature DB >> 26625375

Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes.

Manon Bache1, Graciela Andrei2, Lutz Bindl1, Léon Bofferding1, Jean Bottu1, Christine Géron1, Christoph Neuhäuser1, Sarah Gillemot2, Pierre Fiten3, Ghislain Opdenakker3, Robert Snoeck2.   

Abstract

A neonate suffering from herpes simplex virus type 2 disease with central nervous system involvement developed an early recurrence under acyclovir therapy. Isolates from the cerebrospinal fluid and skin lesions were acyclovir resistant, while viruses from blood and trachea were not. Acyclovir combined with foscavir followed by long-term suppressive acyclovir therapy supported normal neurological development.
© The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  acyclovir resistance; neonatal HSV; virus compartmentalization

Year:  2013        PMID： 26625375     DOI： 10.1093/jpids/pit045

Source DB:  PubMed          Journal:  J Pediatric Infect Dis Soc        ISSN： 2048-7193            Impact factor:   3.164


  2 in total

Review 1.  Immunomodulatory Strategies in Herpes Simplex Virus Encephalitis.

Authors:  Jocelyne Piret; Guy Boivin
Journal:  Clin Microbiol Rev       Date:  2020-02-12       Impact factor: 26.132

Review 2.  Neonatal Herpes Simplex Viral Infections and Acyclovir: An Update.

Authors:  John Brock Harris; Amy P Holmes
Journal:  J Pediatr Pharmacol Ther       Date:  2017 Mar-Apr
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.