Rosa Catarino1, Pierre Vassilakos2, Pierre-Marie Tebeu3, Sonja Schäfer4, Adamo Bongoe5, Patrick Petignat6. 1. Division of Gynecology, Department of Gynecology and Obstetrics, Geneva University Hospitals, 1205 Geneva, Switzerland. Electronic address: rosapintocatarino@gmail.com. 2. Geneva Foundation for Medical Education and Research, 1211 Geneva, Switzerland. Electronic address: pierrevassilakos@bluewin.ch. 3. Department of Gynecology and Obstetrics, University Centre Hospital, Yaoundé, Cameroon. Electronic address: pmtebeu@yahoo.fr. 4. Division of Gynecology, Department of Gynecology and Obstetrics, Geneva University Hospitals, 1205 Geneva, Switzerland. Electronic address: sonja.schafer@hcuge.ch. 5. Department of Gynecology and Obstetrics, Edea Regional Hospital, Edea, Cameroon. Electronic address: bongoecam@yahoo.com. 6. Division of Gynecology, Department of Gynecology and Obstetrics, Geneva University Hospitals, 1205 Geneva, Switzerland. Electronic address: patrick.petignat@hcuge.ch.
Abstract
BACKGROUND: This study used community-based cervical cancer screening for high-risk human-papillomavirus (HPV) to determine demographic and lifestyle factors associated with HPV prevalence and cervical intraepithelial neoplasia grade 2 or worse (CIN2+). METHODS: Women (n=838) aged 25-65 years were recruited in two sequential studies in Cameroon. Demographic and historical data were obtained from participants and specimens were self-collected for HPV-testing using real-time PCR. HPV-positive women underwent biopsy and endocervical curettage. Associations were determined using bivariate analysis and logistic regression. RESULTS: HPV and self-reported HIV prevalence were 39.0% and 9.2%, respectively. Eighteen (9.3%) CIN2+ lesions were found among HPV-positive women. Housewives had a higher risk of being HPV infected (OR=1.60, p=0.010). HIV co-infection (aOR=3.44, p<0.001) and hormonal contraception (aOR=1.97, p=0.007) were associated with increased HPV prevalence. HPV-positive women who used condoms during sexual intercourse were at lower risk of CIN2+ (aOR=0.15, p=0.029). CIN2-3 lesions were found in women younger than 50 years, with a median age of 36 years (31-44). HPV-16/18-positive women had a 4.65-fold increased risk of CIN2+ (p=0.015). CONCLUSIONS: Young, single women and housewives were at higher risk of HPV infection. Preventive strategies for cervical cancer in low-resource settings should target women aged 30-50 years for HPV screening, and should focus treatment and follow-up on HPV-16/18-positive women. Further studies are needed to clarify if other risk factors require attention.
BACKGROUND: This study used community-based cervical cancer screening for high-risk human-papillomavirus (HPV) to determine demographic and lifestyle factors associated with HPV prevalence and cervical intraepithelial neoplasia grade 2 or worse (CIN2+). METHODS:Women (n=838) aged 25-65 years were recruited in two sequential studies in Cameroon. Demographic and historical data were obtained from participants and specimens were self-collected for HPV-testing using real-time PCR. HPV-positive women underwent biopsy and endocervical curettage. Associations were determined using bivariate analysis and logistic regression. RESULTS:HPV and self-reported HIV prevalence were 39.0% and 9.2%, respectively. Eighteen (9.3%) CIN2+ lesions were found among HPV-positive women. Housewives had a higher risk of being HPV infected (OR=1.60, p=0.010). HIV co-infection (aOR=3.44, p<0.001) and hormonal contraception (aOR=1.97, p=0.007) were associated with increased HPV prevalence. HPV-positive women who used condoms during sexual intercourse were at lower risk of CIN2+ (aOR=0.15, p=0.029). CIN2-3 lesions were found in women younger than 50 years, with a median age of 36 years (31-44). HPV-16/18-positive women had a 4.65-fold increased risk of CIN2+ (p=0.015). CONCLUSIONS: Young, single women and housewives were at higher risk of HPV infection. Preventive strategies for cervical cancer in low-resource settings should target women aged 30-50 years for HPV screening, and should focus treatment and follow-up on HPV-16/18-positive women. Further studies are needed to clarify if other risk factors require attention.
Authors: Manuela Viviano; Pierre DeBeaudrap; Pierre-Marie Tebeu; Jovanny T Fouogue; Pierre Vassilakos; Patrick Petignat Journal: Int J Womens Health Date: 2017-02-02
Authors: Anne Jeffries; Consuelo M Beck-Sagué; Ariel Bernardo Marroquin-Garcia; Michael Dean; Virginia McCoy; Diego Aurelio Cordova-Toma; Eric Fenkl; Purnima Madhivanan Journal: Int J Environ Res Public Health Date: 2021-11-25 Impact factor: 3.390
Authors: Juliette Levy; Marie de Preux; Bruno Kenfack; Jessica Sormani; Rosa Catarino; Eveline F Tincho; Chloé Frund; Jovanny T Fouogue; Pierre Vassilakos; Patrick Petignat Journal: Cancer Med Date: 2020-08-05 Impact factor: 4.452