BACKGROUND: The long-term impact of chronic rhinosinusitis (CRS) with or without allergic rhinitis (AR) on asthma is poorly documented. This study analyzed potential associations of ongoing CRS and AR on asthma. METHODS: Using the MarketScan™ claims database, patients with CRS and endoscopic sinus surgery (ESS) in 2010 were identified. The date of first sinusitis was determined for all. Patients with asthma at time of first sinusitis diagnosis were excluded. The remaining patients were grouped based on duration of sinusitis, from first diagnosis to surgery-group 1: 1 to <2 years (n = 181); group 2: 2 to <3 years (n = 195); group 3: 3 to <4 years (n = 292); and group 4: 4 to <5 years (n = 536). Yearly incidence and prevalence of newly diagnosed asthmatics was analyzed for all groups. A secondary analysis evaluated the association between AR and asthma. RESULTS: Preoperatively, yearly incidence of patients with new asthma diagnoses averaged 4.48% (95% confidence interval [CI], 3.93% to 5.11%) and was significantly greater for patients with AR (5.93%; 95% CI, 4.56% to 7.66%) vs non-AR (4.15%; 95% CI, 3.56% to 4.82%); p = 0.03. Postoperatively, yearly incidence of asthma was 0.42% (95% CI, 0.18% to 0.88%). No patient had asthma at time of first diagnosis; however, by time of surgery, 9.4%, 12.8%, 18.2%, and 22.40% of patients had been diagnosed with asthma, in groups 1 through 4, respectively. CONCLUSION: AR was a significant risk factor for asthma in patients with CRS. Medically recalcitrant CRS was associated with high incidence rates of asthma, which declined post-operatively. Patients operated earlier in the disease continuum were therefore at decreased risk of developing asthma.
BACKGROUND: The long-term impact of chronic rhinosinusitis (CRS) with or without allergic rhinitis (AR) on asthma is poorly documented. This study analyzed potential associations of ongoing CRS and AR on asthma. METHODS: Using the MarketScan™ claims database, patients with CRS and endoscopic sinus surgery (ESS) in 2010 were identified. The date of first sinusitis was determined for all. Patients with asthma at time of first sinusitis diagnosis were excluded. The remaining patients were grouped based on duration of sinusitis, from first diagnosis to surgery-group 1: 1 to <2 years (n = 181); group 2: 2 to <3 years (n = 195); group 3: 3 to <4 years (n = 292); and group 4: 4 to <5 years (n = 536). Yearly incidence and prevalence of newly diagnosed asthmatics was analyzed for all groups. A secondary analysis evaluated the association between AR and asthma. RESULTS: Preoperatively, yearly incidence of patients with new asthma diagnoses averaged 4.48% (95% confidence interval [CI], 3.93% to 5.11%) and was significantly greater for patients with AR (5.93%; 95% CI, 4.56% to 7.66%) vs non-AR (4.15%; 95% CI, 3.56% to 4.82%); p = 0.03. Postoperatively, yearly incidence of asthma was 0.42% (95% CI, 0.18% to 0.88%). No patient had asthma at time of first diagnosis; however, by time of surgery, 9.4%, 12.8%, 18.2%, and 22.40% of patients had been diagnosed with asthma, in groups 1 through 4, respectively. CONCLUSION: AR was a significant risk factor for asthma in patients with CRS. Medically recalcitrant CRS was associated with high incidence rates of asthma, which declined post-operatively. Patients operated earlier in the disease continuum were therefore at decreased risk of developing asthma.
Authors: Timothy L Smith; Rodney J Schlosser; Jess C Mace; Jeremiah A Alt; Daniel M Beswick; Adam S DeConde; Kara Y Detwiller; Jose L Mattos; Zachary M Soler Journal: Int Forum Allergy Rhinol Date: 2019-06-17 Impact factor: 3.858
Authors: Carl M Philpott; Sally Erskine; Claire Hopkins; Nirmal Kumar; Shahram Anari; Naveed Kara; Sankalp Sunkaraneni; Jaydip Ray; Allan Clark; Andrew Wilson; Sally Erskine; Carl Philpott; Allan Clark; Claire Hopkins; Alasdair Robertson; Shahzada Ahmed; Naveed Kara; Sean Carrie; Vishnu Sunkaraneni; Jaydip Ray; Shahram Anari; Paul Jervis; Jaan Panesaar; Amir Farboud; Nirmal Kumar; Russell Cathcart; Robert Almeyda; Hisham Khalil; Peter Prinsley; Nicolas Mansell; Mahmoud Salam; Jonathan Hobson; Jane Woods; Emma Coombes Journal: Respir Res Date: 2018-06-27
Authors: Jane Vennik; Caroline Eyles; Mike Thomas; Claire Hopkins; Paul Little; Helen Blackshaw; Anne Schilder; Jim Boardman; Carl M Philpott Journal: BMJ Open Date: 2018-12-19 Impact factor: 2.692
Authors: Auddie M Sweis; Tran B Locke; Jennifer E Douglas; Theodore C Lin; Brian M Sweis; Alyssa M Civantos; David W Kennedy Journal: Int Forum Allergy Rhinol Date: 2020-07-16 Impact factor: 5.426