Literature DB >> 2662408

Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus.

W T Garvey1, T P Huecksteadt, M J Birnbaum.   

Abstract

A prominent feature of diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissues. The contributions of different glucose transport proteins to insulin resistance in rats with streptozotocin-induced diabetes was evaluated. A glucose transporter messenger RNA and its cognate protein that are exclusively expressed in muscle and adipose tissue were specifically depleted in diabetic animals, and these effects were reversed after insulin therapy; a different glucose transporter and its messenger RNA that exhibit a less restricted tissue distribution were not specifically modulated in this way. Depletion of the muscle- and adipose-specific glucose transporter species correlates with and may account for the major portion of cellular insulin resistance in diabetes in these animals.

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Year:  1989        PMID： 2662408     DOI： 10.1126/science.2662408

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  55 in total

1.  Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

Authors:  L F Michael; Z Wu; R B Cheatham; P Puigserver; G Adelmant; J J Lehman; D P Kelly; B M Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

Review 2.  Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes.

Authors:  B B Kahn
Journal:  J Clin Invest       Date:  1992-05       Impact factor: 14.808

3.  The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins.

Authors:  E Wertheimer; S Sasson; E Cerasi; Y Ben-Neriah
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

4.  Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle.

Authors:  N E Block; D R Menick; K A Robinson; M G Buse
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808

5.  Altered expression of glucose transporter isoforms with aging in rats--selective decrease in GluT4 in the fat tissue and skeletal muscle.

Authors:  J L Lin; T Asano; Y Shibasaki; K Tsukuda; H Katagiri; H Ishihara; F Takaku; Y Oka
Journal:  Diabetologia       Date:  1991-07       Impact factor: 10.122

Review 6.  Regulation of gene expression by insulin.

Authors:  R M O'Brien; D K Granner
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

7.  Class II histone deacetylases limit GLUT4 gene expression during adipocyte differentiation.

Authors:  Juston Weems; Ann Louise Olson
Journal:  J Biol Chem       Date:  2010-11-03       Impact factor: 5.157

8.  Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle.

Authors:  J Eriksson; L Koranyi; R Bourey; C Schalin-Jäntti; E Widén; M Mueckler; A M Permutt; L C Groop
Journal:  Diabetologia       Date:  1992-02       Impact factor: 10.122

9.  Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

Authors:  G S Hotamisligil; D L Murray; L N Choy; B M Spiegelman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

10.  Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Authors:  Hui H Zhang; Jingxiang Huang; Katrin Düvel; Bernard Boback; Shulin Wu; Rachel M Squillace; Chin-Lee Wu; Brendan D Manning
Journal:  PLoS One       Date:  2009-07-10       Impact factor: 3.240
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