Literature DB >> 26622779

Role of annexin A6 in cancer.

Houbao Qi1, Shuqing Liu2, Chunmei Guo1, Jiasheng Wang1, Frederick T Greenaway3, Ming-Zhong Sun1.   

Abstract

Annexin A6 (AnxA6) is a member of a conserved superfamily of Ca2+-dependent membrane-binding annexin proteins. It participates in membrane and cytoskeleton organization, cholesterol homeostasis, membrane trafficking, cell adhesion and signal transduction. The expression levels of AnxA6 are closely associated with melanoma, cervical cancer, epithelial carcinoma, breast cancer, gastric cancer, prostate cancer, acute lymphoblastic leukemia, chronic myeloid leukemia, large-cell lymphoma and myeloma. AnxA6 exhibits dual functions in cancer, acting either as a tumor suppressor or promoter, depending on the type of cancer and the degree of malignancy. In several types of cancer, AnxA6 acts via Ras, Ras/MAPK and/or FAK/PI3K signaling pathways by mainly mediating PKCα, p120GAP, Bcr-Abl and YY1. In the present review, the roles of AnxA6 in different types of cancer are summarized.

Entities:  

Keywords:  annexin A6; biomarker; cancer; malignancy; tumor promoter; tumor suppressor

Year:  2015        PMID： 26622779      PMCID： PMC4579822          DOI： 10.3892/ol.2015.3498

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  48 in total

1.  Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions.

Authors:  Amos M Sakwe; Rainelli Koumangoye; Bobby Guillory; Josiah Ochieng
Journal:  Exp Cell Res       Date:  2010-12-24       Impact factor: 3.905

2.  Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain.

Authors:  A Chow; A J Davis; D J Gawler
Journal:  FEBS Lett       Date:  2000-03-03       Impact factor: 4.124

Review 3.  Annexins: linking Ca2+ signalling to membrane dynamics.

Authors:  Volker Gerke; Carl E Creutz; Stephen E Moss
Journal:  Nat Rev Mol Cell Biol       Date:  2005-06       Impact factor: 94.444

4.  Association of p120 ras GAP with endocytic components and colocalization with epidermal growth factor (EGF) receptor in response to EGF stimulation.

Authors:  Z Wang; P S Tung; M F Moran
Journal:  Cell Growth Differ       Date:  1996-01

Review 5.  Early detection and treatment of skin cancer.

Authors:  A F Jerant; J T Johnson; C D Sheridan; T J Caffrey
Journal:  Am Fam Physician       Date:  2000-07-15       Impact factor: 3.292

6.  Annexin A6 inhibits Ras signalling in breast cancer cells.

Authors:  S Vilá de Muga; P Timpson; L Cubells; R Evans; T E Hayes; C Rentero; A Hegemann; M Reverter; J Leschner; A Pol; F Tebar; R J Daly; C Enrich; T Grewal
Journal:  Oncogene       Date:  2008-10-13       Impact factor: 9.867

7.  p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia.

Authors:  A Pierce; P J Owen-Lynch; E Spooncer; T M Dexter; A D Whetton
Journal:  Oncogene       Date:  1998-08-06       Impact factor: 9.867

8.  Comparative proteomics of human endothelial cell caveolae and rafts using two-dimensional gel electrophoresis and mass spectrometry.

Authors:  Richard R Sprenger; Dave Speijer; Jaap Willem Back; Chris G De Koster; Hans Pannekoek; Anton J G Horrevoets
Journal:  Electrophoresis       Date:  2004-01       Impact factor: 3.535

9.  The relationship between epidermal growth factor receptors and the terminal differentiation of A431 carcinoma cells.

Authors:  I C King; A C Sartorelli
Journal:  Biochem Biophys Res Commun       Date:  1986-11-14       Impact factor: 3.575

10.  Extracellular annexin VI expression is associated with divalent cation-dependent endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells.

Authors:  R J Tressler; T Yeatman; G L Nicolson
Journal:  Exp Cell Res       Date:  1994-12       Impact factor: 3.905
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  24 in total

1.  Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift.

Authors:  Jung Eun Park; Bamaprasad Dutta; Shun Wilford Tse; Nikhil Gupta; Chee Fan Tan; Jee Keem Low; Kheng Wei Yeoh; Oi Lian Kon; James P Tam; Siu Kwan Sze
Journal:  Oncogene       Date:  2019-03-12       Impact factor: 9.867

Review 2.  Annexin Animal Models-From Fundamental Principles to Translational Research.

Authors:  Thomas Grewal; Carles Rentero; Carlos Enrich; Mohamed Wahba; Carsten A Raabe; Ursula Rescher
Journal:  Int J Mol Sci       Date:  2021-03-26       Impact factor: 5.923

Review 3.  Therapy-induced chemoexosomes: Sinister small extracellular vesicles that support tumor survival and progression.

Authors:  Shyam K Bandari; Kaushlendra Tripathi; Sunil Rangarajan; Ralph D Sanderson
Journal:  Cancer Lett       Date:  2020-08-26       Impact factor: 8.679

4.  Annexin A6 protein is downregulated in human hepatocellular carcinoma.

Authors:  Elisabeth M Meier; Lisa Rein-Fischboeck; Rebekka Pohl; Josef Wanninger; Andrew J Hoy; Thomas Grewal; Kristina Eisinger; Sabrina Krautbauer; Gerhard Liebisch; Thomas S Weiss; Christa Buechler
Journal:  Mol Cell Biochem       Date:  2016-06-23       Impact factor: 3.396

Review 5.  The complexities of PKCα signaling in cancer.

Authors:  Adrian R Black; Jennifer D Black
Journal:  Adv Biol Regul       Date:  2020-11-23

Review 6.  Functional Association between Regulatory RNAs and the Annexins.

Authors:  Katia Monastyrskaya
Journal:  Int J Mol Sci       Date:  2018-02-16       Impact factor: 5.923

7.  Construction of a Promising Tumor-Infiltrating CD8+ T Cells Gene Signature to Improve Prediction of the Prognosis and Immune Response of Uveal Melanoma.

Authors:  Yifang Sun; Jian Wu; Yonggang Yuan; Yumin Lu; Ming Luo; Ling Lin; Shengsheng Ma
Journal:  Front Cell Dev Biol       Date:  2021-05-28

8.  Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer.

Authors:  Ting Li; Zhonghua Tao; Yihui Zhu; Xiaojia Liu; Leiping Wang; Yiqun Du; Jun Cao; Biyun Wang; Jian Zhang; Xichun Hu
Journal:  Cell Death Dis       Date:  2021-07-08       Impact factor: 8.469

9.  Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.

Authors:  David W Greening; Hong Ji; Maoshan Chen; Bruce W S Robinson; Ian M Dick; Jenette Creaney; Richard J Simpson
Journal:  Sci Rep       Date:  2016-09-08       Impact factor: 4.379

10.  Passenger strand of miR-145-3p acts as a tumor-suppressor by targeting MYO1B in head and neck squamous cell carcinoma.

Authors:  Yasutaka Yamada; Keiichi Koshizuka; Toyoyuki Hanazawa; Naoko Kikkawa; Atsushi Okato; Tetsuya Idichi; Takayuki Arai; Sho Sugawara; Koji Katada; Yoshitaka Okamoto; Naohiko Seki
Journal:  Int J Oncol       Date:  2017-11-06       Impact factor: 5.650
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