Literature DB >> 26622725

Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells.

Jing Jing Yu1, Long Dian Zhou2, Tian Tian Zhao1, Wei Bai1, Jing Zhou1, Wei Zhang1.   

Abstract

Elevated expression of Aurora-B affects cell apoptosis and proliferation in a variety of solid tumors. However, the role of Aurora-B has been poorly evaluated in non-small cell lung cancer (NSCLC). In the present study, it was found that Aurora-B was overexpressed in tissue specimens obtained from 174 patients with lung cancer. It was also demonstrated that knockdown of Aurora-B induces apoptosis and inhibits the growth of lung cancer A549 cells in vitro and in vivo. Furthermore, it was found that silencing Aurora-B decreased the activity of the phosphoinositide 3-kinase (PI3K)/AKT pathway. Therefore, it was concluded that knockdown of Aurora-B induces apoptosis and inhibits growth in NSCLC A549 cells, in addition to inhibiting the activity of the PI3K/AKT signaling pathway. Targeting Aurora-B may provide a novel target for lung cancer therapy.

Entities:  

Keywords:  Aurora-B; PI3K/AKT signaling pathway; apoptosis; growth; non-small cell lung cancer

Year:  2015        PMID： 26622725      PMCID： PMC4533708          DOI： 10.3892/ol.2015.3467

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  24 in total

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2.  Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells.

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Authors:  Wen-rui Wang; Sheng-sheng Yang; Jing-xiang Lin; Zhi-yong Zeng; Dao-ming Liu; Hong-tao Liu
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2009-09

Review 4.  Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer.

Authors:  Claudia Fumarola; Mara A Bonelli; Pier Giorgio Petronini; Roberta R Alfieri
Journal:  Biochem Pharmacol       Date:  2014-05-24       Impact factor: 5.858

5.  [Survival analysis and the effects of prognostic factors in patients treated for osteosarcoma].

Authors:  Harzem Ozger; Levent Eralp; Ata Can Atalar; Berkin Toker; Inci Ayan; Rejin Kebudi; Sevil Bağbek; Mert Başaran; Fulya Ağaoğlu; Yavuz Dizdar; Bilge Bilgiç
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Review 6.  Molecular pathogenesis of lung cancer and potential translational applications.

Authors:  John D Minna; Kwun Fong; Sabine Zöchbauer-Müller; Adi F Gazdar
Journal:  Cancer J       Date:  2002 May-Jun       Impact factor: 3.360

7.  ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture.

Authors:  Zi-Jie Long; Jie Xu; Min Yan; Jian-Gang Zhang; Zhong Guan; Da-Zhi Xu; Xian-Ren Wang; Jine Yao; Fei-Meng Zheng; Guo-Liang Chu; Jun-Xia Cao; Yi-Xin Zeng; Quentin Liu
Journal:  Cell Cycle       Date:  2008-03-12       Impact factor: 4.534

Review 8.  Aurora kinase inhibitors: Potential molecular-targeted drugs for gynecologic malignant tumors.

Authors:  Kiyoko Umene; Kouji Banno; Iori Kisu; Megumi Yanokura; Yuya Nogami; Kosuke Tsuji; Kenta Masuda; Arisa Ueki; Yusuke Kobayashi; Wataru Yamagami; Hiroyuki Nomura; Eiichiro Tominaga; Nobuyuki Susumu; Daisuke Aoki
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9.  Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation.

Authors:  Rosanna Sorrentino; Silvana Libertini; Pier Lorenzo Pallante; Giancarlo Troncone; Lucio Palombini; Vassilios Bavetsias; Daniela Spalletti-Cernia; Paolo Laccetti; Spiros Linardopoulos; Paolo Chieffi; Alfredo Fusco; Giuseppe Portella
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10.  Silencing miR-21 sensitizes non-small cell lung cancer A549 cells to ionizing radiation through inhibition of PI3K/Akt.

Authors:  Yongfu Ma; Hui Xia; Yang Liu; Min Li
Journal:  Biomed Res Int       Date:  2014-04-07       Impact factor: 3.411
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  4 in total

1.  OCT4 controls mitotic stability and inactivates the RB tumor suppressor pathway to enhance ovarian cancer aggressiveness.

Authors:  E Comisso; M Scarola; M Rosso; S Piazza; S Marzinotto; Y Ciani; M Orsaria; L Mariuzzi; C Schneider; S Schoeftner; R Benetti
Journal:  Oncogene       Date:  2017-03-20       Impact factor: 9.867

2.  Expression and clinical significance of AURKB gene in lung adenocarcinoma: Analysis based on the data-mining of bioinformatic database.

Authors:  Xiaoyan Gao; Aigui Jiang; Yahui Shen; Huiyu Lu; Rong Chen
Journal:  Medicine (Baltimore)       Date:  2021-08-06       Impact factor: 1.817

3.  Quercetin suppresses lung cancer growth by targeting Aurora B kinase.

Authors:  Zhu Xingyu; Ma Peijie; Peng Dan; Wang Youg; Wang Daojun; Chen Xinzheng; Zhang Xijun; Song Yangrong
Journal:  Cancer Med       Date:  2016-10-05       Impact factor: 4.452

4.  An Engineered Mouse to Identify Proliferating Cells and Their Derivatives.

Authors:  Jihyun Jang; Kurt A Engleka; Feiyan Liu; Li Li; Guang Song; Jonathan A Epstein; Deqiang Li
Journal:  Front Cell Dev Biol       Date:  2020-05-25
  4 in total

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