Joanna Raszeja-Wyszomirska1, Ewa Wunsch2, Marek Krawczyk3, Eirini I Rigopoulou4, Konrad Kostrzewa5, Gary L Norman6, Dimitrios P Bogdanos7, Piotr Milkiewicz8. 1. Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw, Warsaw, Poland. 2. Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland. 3. Department of General, Transplant and Liver Surgery of the Medical University of Warsaw, Warsaw, Poland. 4. Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. 5. Warsaw School of Economics, Warsaw, Poland. 6. Inova Diagnostics, San Diego, CA, United States. 7. Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece; Liver Sciences, Division of Transplantation Immunology and Mucosal Biology, King's College London School of Medicine, King's College Hospital, London, UK. 8. Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery of the Medical University of Warsaw, Warsaw, Poland; Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland. Electronic address: milkiewp@sci.pum.edu.pl.
Abstract
BACKGROUND: Most patients with primary biliary cirrhosis (PBC) have impaired health related quality of life (HRQoL), as assessed by PBC-specific HRQoL (PBC-40) and generic (SF-36) questionnaires. Data on the applicability of PBC-27, a shorter version of PBC-40, have been limited. AIMS: To assess HRQoL in Polish PBC patients, applying PBC-40, PBC-27 and SF-36 and to associate clinical or laboratory parameters with HRQoL factors. METHODS: A total of 205 PBC patients (188 females) were analyzed using PBC-40, PBC-27 and SF-36; 85 disease-free demographically matched (in terms of age, gender, ethnicity) individuals were used as normal controls. RESULTS: When compared to controls, PBC patients had significantly impaired HRQoL across all the domains of SF-36. HRQoL impairment by PBC-40 and PBC-27 was comparable between cirrhotics and non-cirrhotics, except for significantly worse Itch in cirrhotics (6.5±4.9 vs 5.1±4.3; P=0.03). In PBC-40/27, alkaline phosphatase (ALP) levels correlated with itch (P=0.0003). Female patients had marginally impaired cognitive function compared to males by PBC-40 (P=0.06). Other gender-related differences were not found. Anti-gp210 positive, as well as AMA negative PBC patients, had worse HRQoL features in itch and social/emotional domains of PBC-40/PBC-27 questionnaires. Very strong correlations (P<0.0001) between PBC-40/PBC-27 and SF-36 were seen for several domains. CONCLUSIONS: HRQoL is significantly impaired in Polish patients with PBC, independently of gender and disease severity. PBC-40 and PBC-27 questionnaires are efficient in detecting HRQoL impairment in Polish PBC patients. The striking correlation between PBC-40/PBC-27 and SF-36 confirms the usefulness of the former HRQoL measures in PBC patients from Central-Eastern Europe.
BACKGROUND: Most patients with primary biliary cirrhosis (PBC) have impaired health related quality of life (HRQoL), as assessed by PBC-specific HRQoL (PBC-40) and generic (SF-36) questionnaires. Data on the applicability of PBC-27, a shorter version of PBC-40, have been limited. AIMS: To assess HRQoL in Polish PBC patients, applying PBC-40, PBC-27 and SF-36 and to associate clinical or laboratory parameters with HRQoL factors. METHODS: A total of 205 PBC patients (188 females) were analyzed using PBC-40, PBC-27 and SF-36; 85 disease-free demographically matched (in terms of age, gender, ethnicity) individuals were used as normal controls. RESULTS: When compared to controls, PBC patients had significantly impaired HRQoL across all the domains of SF-36. HRQoL impairment by PBC-40 and PBC-27 was comparable between cirrhotics and non-cirrhotics, except for significantly worse Itch in cirrhotics (6.5±4.9 vs 5.1±4.3; P=0.03). In PBC-40/27, alkaline phosphatase (ALP) levels correlated with itch (P=0.0003). Female patients had marginally impaired cognitive function compared to males by PBC-40 (P=0.06). Other gender-related differences were not found. Anti-gp210 positive, as well as AMA negative PBC patients, had worse HRQoL features in itch and social/emotional domains of PBC-40/PBC-27 questionnaires. Very strong correlations (P<0.0001) between PBC-40/PBC-27 and SF-36 were seen for several domains. CONCLUSIONS: HRQoL is significantly impaired in Polish patients with PBC, independently of gender and disease severity. PBC-40 and PBC-27 questionnaires are efficient in detecting HRQoL impairment in Polish PBC patients. The striking correlation between PBC-40/PBC-27 and SF-36 confirms the usefulness of the former HRQoL measures in PBC patients from Central-Eastern Europe.
Authors: Urszula Wasik; Ewa Wunsch; Gary L Norman; Eirini I Rigopoulou; Dimitrios P Bogdanos; Piotr Milkiewicz; Małgorzata Milkiewicz Journal: J Immunol Res Date: 2017-02-19 Impact factor: 4.818
Authors: Lorenzo Montali; Andrea Gragnano; Massimo Miglioretti; Alessandra Frigerio; Luca Vecchio; Alessio Gerussi; Laura Cristoferi; Vincenzo Ronca; Daphne D'Amato; Sarah Elizabeth O'Donnell; Clara Mancuso; Martina Lucà; Minami Yagi; Anna Reig; Laura Jopson; Sesé Pilar; Dave Jones; Albert Pares; George Mells; Atsushi Tanaka; Marco Carbone; Pietro Invernizzi Journal: J Transl Autoimmun Date: 2021-01-06
Authors: Ewa Wunsch; Marcin Krawczyk; Malgorzata Milkiewicz; Jocelyn Trottier; Olivier Barbier; Markus F Neurath; Frank Lammert; Andreas E Kremer; Piotr Milkiewicz Journal: Sci Rep Date: 2016-08-10 Impact factor: 4.379