Literature DB >> 26620770

The synthesis of sterically hindered amines by a direct reductive amination of ketones.

Niyaz Z Yagafarov1, Pavel N Kolesnikov1, Dmitry L Usanov1, Valentin V Novikov1, Yulia V Nelyubina1, Denis Chusov1.   

Abstract

An atom-economical methodology for the synthesis of sterically hindered tertiary amines was developed, which is based on complementary Rh- and Ru-catalyzed direct reductive amination of ketones with primary and secondary amines using carbon monoxide as a deoxygenating agent.

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Year:  2016        PMID: 26620770     DOI: 10.1039/c5cc08577b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  2 in total

1.  Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction.

Authors:  Yage Zhou; Dan Wu; Willinton Yesid Hernández; Changru Ma; Huangyang Su; Vitaly Ordomsky
Journal:  RSC Adv       Date:  2019-03-28       Impact factor: 3.361

2.  Underlying Mechanisms of Reductive Amination on Pd-Catalysts: The Unique Role of Hydroxyl Group in Generating Sterically Hindered Amine.

Authors:  Zeng Hong; Xin Ge; Shaodong Zhou
Journal:  Int J Mol Sci       Date:  2022-07-10       Impact factor: 6.208

  2 in total

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