Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Pioneering biased ligand offers efficacy with reduced on-target toxicity.

× No keyword cloud information.

1 in total

Review 1. Teaching old receptors new tricks: biasing seven-transmembrane receptors.

Authors: Sudarshan Rajagopal; Keshava Rajagopal; Robert J Lefkowitz
Journal: Nat Rev Drug Discov Date: 2010-05 Impact factor: 84.694

1 in total

4 in total

1. Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons.

Authors: Matthew R Sapio; John K Neubert; Danielle M LaPaglia; Dragan Maric; Jason M Keller; Stephen J Raithel; Eric L Rohrs; Ethan M Anderson; John A Butman; Robert M Caudle; Dorothy C Brown; John D Heiss; Andrew J Mannes; Michael J Iadarola
Journal: J Clin Invest Date: 2018-03-19 Impact factor: 14.808

2. A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity.

Authors: Marta Sanchez-Soto; Ravi Kumar Verma; Blair K A Willette; Elizabeth C Gonye; Annah M Moore; Amy E Moritz; Comfort A Boateng; Hideaki Yano; R Benjamin Free; Lei Shi; David R Sibley
Journal: Sci Signal Date: 2020-02-04 Impact factor: 8.192

3. G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.

Authors: Lauriane Onfroy; Ségolène Galandrin; Stéphanie M Pontier; Marie-Hélène Seguelas; Du N'Guyen; Jean-Michel Sénard; Céline Galés
Journal: Sci Rep Date: 2017-08-11 Impact factor: 4.379

4. Novel inverse agonists for the orphan G protein-coupled receptor 6.

Authors: Alyssa S Laun; Sarah H Shrader; Zhao-Hui Song
Journal: Heliyon Date: 2018-11-16

4 in total