John S Schieffelin1, Paige L Williams2, Divna Djokic3, Jeffrey P Anderson4, Sharon Nachman4, James M Oleske5, George R Seage4, Russell B Van Dyke1. 1. Section of Pediatric Infectious Disease, Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana. 2. Center for Biostatistics in AIDS Research, and. 3. Section of Pediatric Infectious Diseases, Department of Pediatrics, State University of New York at Stony Brook School of Medicine. 4. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, Boston, Massachusetts. 5. UMDNJ New Jersey Medical School, Newark.
Abstract
BACKGROUND: Central nervous system (CNS) vasculopathy has been reported in human immunodeficiency virus-infected (HIV+) adults and children. In children, it often presents with HIV encephalopathy, stroke, or intracerebral aneurysms. The etiology, incidence, and risk factors of HIV-associated CNS vasculopathy in children are unknown. METHODS: We identified HIV+ children with a diagnosis of vasculopathy or other cerebrovascular events among children enrolled between 1993 and 2004 in 2 prospective, multicenter cohort studies. Demographic and laboratory data, history of antiretroviral use, and signs, symptoms, and diagnostic studies pertaining to the CNS event were reviewed. RESULTS: Among the 3338 HIV+ children, 51 had diagnoses that suggested CNS vasculopathy. Of these, 12 (24%) were included in this analysis, after excluding those with alternative diagnoses and those from closed sites. Among these 12, 4 (33%) were female, 4 (33%) were white, and 10 (83%) had perinatal HIV. Their average age at the event was 10.8 years with a median CD4 count of 22 cells/mm(3) and median HIV-1 viral load of 94 304 copies/mL. Fifty-eight percent of subjects had a history of opportunistic infections before the CNS event. Fifty percent had cerebral aneurysms on imaging. The overall incidence among HIV+ subjects was 3.4 cases per 10 000 person-years (95% confidence interval, 1.8-6.0). CONCLUSIONS: CNS vasculopathy in HIV+ children is uncommon but more common than in the general pediatric population. Cerebral aneurysms are the most common manifestation. Although the pathogenesis remains unclear, older children and those with low CD4 counts and high HIV viral loads are at the highest risk.
BACKGROUND: Central nervous system (CNS) vasculopathy has been reported in human immunodeficiency virus-infected (HIV+) adults and children. In children, it often presents with HIV encephalopathy, stroke, or intracerebral aneurysms. The etiology, incidence, and risk factors of HIV-associated CNS vasculopathy in children are unknown. METHODS: We identified HIV+ children with a diagnosis of vasculopathy or other cerebrovascular events among children enrolled between 1993 and 2004 in 2 prospective, multicenter cohort studies. Demographic and laboratory data, history of antiretroviral use, and signs, symptoms, and diagnostic studies pertaining to the CNS event were reviewed. RESULTS: Among the 3338 HIV+ children, 51 had diagnoses that suggested CNS vasculopathy. Of these, 12 (24%) were included in this analysis, after excluding those with alternative diagnoses and those from closed sites. Among these 12, 4 (33%) were female, 4 (33%) were white, and 10 (83%) had perinatal HIV. Their average age at the event was 10.8 years with a median CD4 count of 22 cells/mm(3) and median HIV-1 viral load of 94 304 copies/mL. Fifty-eight percent of subjects had a history of opportunistic infections before the CNS event. Fifty percent had cerebral aneurysms on imaging. The overall incidence among HIV+ subjects was 3.4 cases per 10 000 person-years (95% confidence interval, 1.8-6.0). CONCLUSIONS: CNS vasculopathy in HIV+ children is uncommon but more common than in the general pediatric population. Cerebral aneurysms are the most common manifestation. Although the pathogenesis remains unclear, older children and those with low CD4 counts and high HIV viral loads are at the highest risk.
Authors: Colleen L Schneider; Sarah Mohajeri-Moghaddam; Esau G Mbewe; Pelekelo P Kabundula; Owen Dean; Alexandra Buda; Michael J Potchen; Sylvia Mwanza-Kabaghe; Deanna Saylor; Heather R Adams; Gretchen L Birbeck; David R Bearden Journal: Pediatr Neurol Date: 2020-08-05 Impact factor: 3.372
Authors: Mohamad G Bakhaidar; Naushad A Ahamed; Mohammed A Almekhlafi; Saleh S Baeesa Journal: Neurosciences (Riyadh) Date: 2015-07 Impact factor: 0.906