Literature DB >> 26618281

The role of NANOG transcriptional factor in the development of malignant phenotype of cancer cells.

Natalia Gawlik-Rzemieniewska1, Ilona Bednarek1.   

Abstract

NANOG is a transcription factor that is involved in the self-renewal of embryonic stem cells (ES) and is a critical factor for the maintenance of the undifferentiated state of pluripotent cells. Extensive data in the literature show that the NANOG gene is aberrantly expressed during the development of malignancy in cancer cells. ES and cancer stem cells (CSCs), a subpopulation of cancer cells within the tumor, are thought to share common phenotypic properties. This review describes the role of NANOG in cancer cell proliferation, epithelial-mesenchymal transition (EMT), apoptosis and metastasis. In addition, this paper illustrates a correlation between NANOG and signal transducer and activator of transcription 3 (STAT3) in the maintenance of cancer stem cell properties and multidrug resistance. Together, the available data demonstrate that NANOG is strictly involved in the process of carcinogenesis and is a potential prognostic marker of malignant tumors.

Entities:  

Keywords:  Angiogenesis; NANOG; STAT3; apoptosis; cancer; cancer stem cells; metastasis

Mesh：

Substances：

Year:  2016        PMID： 26618281      PMCID： PMC4848008          DOI： 10.1080/15384047.2015.1121348

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  70 in total

1.  Hedgehog controls neural stem cells through p53-independent regulation of Nanog.

Authors:  Agnese Po; Elisabetta Ferretti; Evelina Miele; Enrico De Smaele; Arianna Paganelli; Gianluca Canettieri; Sonia Coni; Lucia Di Marcotullio; Mauro Biffoni; Luca Massimi; Concezio Di Rocco; Isabella Screpanti; Alberto Gulino
Journal:  EMBO J       Date:  2010-06-25       Impact factor: 11.598

2.  NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.

Authors:  Erin E Kohler; Colleen E Cowan; Ishita Chatterjee; Asrar B Malik; Kishore K Wary
Journal:  Blood       Date:  2010-11-30       Impact factor: 22.113

3.  Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma.

Authors:  Juanjuan Shan; Junjie Shen; Limei Liu; Feng Xia; Chuan Xu; Guangjie Duan; Yanmin Xu; Qinghua Ma; Zhi Yang; Qianzhen Zhang; Leina Ma; Jia Liu; Senlin Xu; Xiaochu Yan; Ping Bie; Youhong Cui; Xiu-wu Bian; Cheng Qian
Journal:  Hepatology       Date:  2012-07-12       Impact factor: 17.425

4.  MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation.

Authors:  Cheng-Chia Yu; Yi-Wei Chen; Guang-Yuh Chiou; Lo-Lin Tsai; Pin-I Huang; Charn-Yung Chang; Ling-Ming Tseng; Shih-Hwa Chiou; Sang-Hue Yen; Ming-Yung Chou; Pen-Yuan Chu; Wen-Liang Lo
Journal:  Oral Oncol       Date:  2011-02-02       Impact factor: 5.337

5.  Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.

Authors:  Shih-Hwa Chiou; Mong-Lien Wang; Yu-Ting Chou; Chi-Jen Chen; Chun-Fu Hong; Wang-Ju Hsieh; Hsin-Tzu Chang; Ying-Shan Chen; Tzu-Wei Lin; Han-Sui Hsu; Cheng-Wen Wu
Journal:  Cancer Res       Date:  2010-12-15       Impact factor: 12.701

Review 6.  Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications.

Authors:  Suyun Huang
Journal:  Clin Cancer Res       Date:  2007-03-01       Impact factor: 12.531

7.  Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma.

Authors:  Ting Lin; Yan-Qing Ding; Jian-Ming Li
Journal:  Med Oncol       Date:  2011-02-20       Impact factor: 3.064

8.  Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.

Authors:  Pierre-Yves Bourillot; Irène Aksoy; Valerie Schreiber; Florence Wianny; Herbert Schulz; Oliver Hummel; Norbert Hubner; Pierre Savatier
Journal:  Stem Cells       Date:  2009-08       Impact factor: 6.277

9.  Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on embryo developmental progression.

Authors:  Kyung-Bon Lee; Joseph K Folger; Sandeep K Rajput; George W Smith
Journal:  Reprod Biol Endocrinol       Date:  2014-07-15       Impact factor: 5.211

10.  NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.

Authors:  Hannah T Stuart; Anouk L van Oosten; Aliaksandra Radzisheuskaya; Graziano Martello; Anzy Miller; Sabine Dietmann; Jennifer Nichols; José C R Silva
Journal:  Curr Biol       Date:  2014-01-23       Impact factor: 10.834
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  30 in total

Review 1.  RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness.

Authors:  Huarong Chen; Yifei Wang; Hao Su; Xiaoting Zhang; Hongyan Chen; Jun Yu
Journal:  Front Cell Dev Biol       Date:  2022-07-04

2.  Long noncoding RNA MEG3 suppresses cell proliferation, migration and invasion, induces apoptosis and paclitaxel-resistance via miR-4513/PBLD axis in breast cancer cells.

Authors:  Mingzhi Zhu; Fang Wang; Hailong Mi; Lin Li; Jing Wang; Mingli Han; Yuanting Gu
Journal:  Cell Cycle       Date:  2020-10-30       Impact factor: 4.534

3.  PHF20 collaborates with PARP1 to promote stemness and aggressiveness of neuroblastoma cells through activation of SOX2 and OCT4.

Authors:  Wenyong Long; Wei Zhao; Bo Ning; Jing Huang; Junjun Chu; Linfeng Li; Qianquan Ma; Changsheng Xing; Helen Y Wang; Qing Liu; Rong-Fu Wang
Journal:  J Mol Cell Biol       Date:  2018-04-01       Impact factor: 6.216

4.  Prognostic implication of SOX2 expression in small intestinal adenocarcinoma.

Authors:  Jeong Won Kim; Joon-Yong Chung; Kris Ylaya; Yoonho Park; Sun-Young Jun; Seung-Mo Hong; Stephen M Hewitt
Journal:  Virchows Arch       Date:  2020-10-25       Impact factor: 4.064

5.  Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma.

Authors:  Chenyu Ding; Xuehan Yi; Xiangrong Chen; Zanyi Wu; Honghai You; Xiaoyong Chen; Gaoqi Zhang; Yong Sun; Xingyao Bu; Xiyue Wu; Zhangya Lin; Jianjun Gu; Yuanxiang Lin; Dezhi Kang
Journal:  J Exp Clin Cancer Res       Date:  2021-05-11

6.  RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.

Authors:  Allison E Bridges; Sabarish Ramachandran; Rajneesh Pathania; Utkarsh Parwal; Adrienne Lester; Pragya Rajpurohit; Daley S Morera; Nikhil Patel; Nagendra Singh; Hasan Korkaya; Santhakumar Manicassamy; Puttur D Prasad; Vinata B Lokeshwar; Bal L Lokeshwar; Vadivel Ganapathy; Muthusamy Thangaraju
Journal:  Cancer Res       Date:  2020-07-14       Impact factor: 13.312

7.  Visualization of early prostatic adenocarcinoma as a stem cell disease.

Authors:  Maggie Y Jiang; Tammy L Lee; Su-Shin Hao; Sepi Mahooti; Stephen M Baird; Daniel J Donoghue; Martin Haas
Journal:  Oncotarget       Date:  2016-11-15

8.  NANOG regulates epithelial-mesenchymal transition and chemoresistance in ovarian cancer.

Authors:  Shan Qin; Yanfang Li; Xuexia Cao; Jiexian Du; Xianghua Huang
Journal:  Biosci Rep       Date:  2017-01-10       Impact factor: 3.840

9.  Jorunnamycin A Suppresses Stem-Like Phenotypes and Sensitizes Cisplatin-Induced Apoptosis in Cancer Stem-Like Cell-Enriched Spheroids of Human Lung Cancer Cells.

Authors:  Somruethai Sumkhemthong; Supakarn Chamni; Gea U Ecoy; Pornchanok Taweecheep; Khanit Suwanborirux; Eakachai Prompetchara; Pithi Chanvorachote; Chatchai Chaotham
Journal:  Mar Drugs       Date:  2021-05-03       Impact factor: 5.118

10.  RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.

Authors:  Allison E Bridges; Sabarish Ramachandran; Kavin Tamizhmani; Utkarsh Parwal; Adrienne Lester; Pragya Rajpurohit; Daley S Morera; Sarrah L Hasanali; Pachiappan Arjunan; Ravirajsinh N Jedeja; Nikhil Patel; Pamela M Martin; Hasan Korkaya; Nagendra Singh; Santhakumar Manicassamy; Puttur D Prasad; Vinata B Lokeshwar; Bal L Lokeshwar; Vadivel Ganapathy; Muthusamy Thangaraju
Journal:  Mol Cancer Res       Date:  2021-06-07       Impact factor: 5.852
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