Wei-Hua Lin1, Feng Xu1, Long Bao1, Shi-Ying Zheng2, Wen-Ming Shen3. 1. Department of Emergency Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China. 2. Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China. 3. Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu Province, China ; The Affiliated Wujin People's Hospital of Jiangsu University Changzhou 213000, Jiangsu Province, China.
Abstract
OBJECTIVE: To explore the special significances in advantages of using anti-inflammatory drugs, such as amelioration of growing conditions and the promotion of cell growth. METHODS: Utilizing anti-adhesive effects of synthetic E-selectins, we observed the changes of inflammatory cytokines (TNF-α, IL-1β) contented in brain tissues and rat serums in rats hind cerebral ischemia-reperfusion models. Both growth and expression of endogenetic/exogenous neurological stem cells were detected after ameliorated local microenvironment. RESULTS: The contents of TNF-α and IL-1β were decreased in brain tissues and rat serums after applying synthetic E-selectins. Expression of exogenous neurological stem cells was enhanced. Animal neurological functions improved. CONCLUSION: Anti-inflammatory therapy in early stage could enhance proliferation of stem cells so that it has vital significations in treating cerebrovascular diseases.
OBJECTIVE: To explore the special significances in advantages of using anti-inflammatory drugs, such as amelioration of growing conditions and the promotion of cell growth. METHODS: Utilizing anti-adhesive effects of synthetic E-selectins, we observed the changes of inflammatory cytokines (TNF-α, IL-1β) contented in brain tissues and rat serums in rats hind cerebral ischemia-reperfusion models. Both growth and expression of endogenetic/exogenous neurological stem cells were detected after ameliorated local microenvironment. RESULTS: The contents of TNF-α and IL-1β were decreased in brain tissues and rat serums after applying synthetic E-selectins. Expression of exogenous neurological stem cells was enhanced. Animal neurological functions improved. CONCLUSION: Anti-inflammatory therapy in early stage could enhance proliferation of stem cells so that it has vital significations in treating cerebrovascular diseases.
Entities:
Keywords:
Ischemia-reperfusion; endogenetic/exogenous never stem cells; inflammatory cytokines; synthetic e-selectins