Literature DB >> 26617846

MiR-223 inhibited cell metastasis of human cervical cancer by modulating epithelial-mesenchymal transition.

Yaling Tang1, Yifeng Wang2, Qionghua Chen3, Naxuan Qiu3, Yan Zhao4, Xueye You5.   

Abstract

Accumulating evidence have emerged important roles for microRNAs (miRNAs) participating in epithelial-mesenchymal transition (EMT) process and are associated with metastasis in cervical cancer. We hypothesized that miR-223 played an important role in cell metastasis of cervical cancer. Here, we found miR-223 was downregulated in human cervical cancer cell lines and clinical tumor tissues. Result of wound healing and cell migration assays revealed that miR-223 inhibited cell migration, whereas miR-223-in showed the opposite effect. In terms of mechanism, miR-223 influenced the expression of the EMT-associated proteins by upregulating the epithelial markers E-cadherin and α-cadherin and downregulating the mesenchymal marker vimentin. In conclusion, miR-223 inhibited cell metastasis of human cervical cancer by modulating epithelial-mesenchymal transition.

Entities:  

Keywords:  cell metastasis; human cervical cancer; miR-223

Mesh：

Substances：

Year:  2015        PMID： 26617846      PMCID： PMC4637661     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  24 in total

1.  MicroRNA-223 regulates FOXO1 expression and cell proliferation.

Authors:  Lihui Wu; Huihui Li; Cheng You Jia; Wei Cheng; Mei Yu; Min Peng; Yuanqing Zhu; Qianlei Zhao; Yi Wei Dong; Kang Shao; Anle Wu; Xing Zhong Wu
Journal:  FEBS Lett       Date:  2012-03-08       Impact factor: 4.124

2.  miR-210, a modulator of hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cell.

Authors:  Lu Ding; Le Zhao; Wei Chen; Ting Liu; Zhen Li; Xu Li
Journal:  Int J Clin Exp Med       Date:  2015-02-15

3.  MicroRNA-221 promotes human non-small cell lung cancer cell H460 growth.

Authors:  Yiming Xu; Chongjun Zhong; Shengguang Ding; Haitao Huang; Zhenya Shen
Journal:  Int J Clin Exp Med       Date:  2015-02-15

4.  MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression.

Authors:  Fei Shen; Wen-Song Cai; Zhe Feng; Jiang-Lin Li; Ji-Wei Chen; Jie Cao; Bo Xu
Journal:  Tumour Biol       Date:  2014-11-19

Review 5.  The epithelial to mesenchymal transition in pancreatic cancer: A systematic review.

Authors:  Mircea Beuran; Ionut Negoi; Sorin Paun; Adriana Daniela Ion; Coralia Bleotu; Ruxandra Irina Negoi; Sorin Hostiuc
Journal:  Pancreatology       Date:  2015-03-07       Impact factor: 3.996

6.  miR-212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical cancer cells.

Authors:  Jian-Li Zhao; Le Zhang; Xu Guo; Jing-Hua Wang; Wen Zhou; Min Liu; Xin Li; Hua Tang
Journal:  IUBMB Life       Date:  2015-05-19       Impact factor: 3.885

Review 7.  The epithelial-mesenchymal transition (EMT) phenomenon.

Authors:  P Savagner
Journal:  Ann Oncol       Date:  2010-10       Impact factor: 32.976

8.  EZH2-specific microRNA-98 inhibits human ovarian cancer stem cell proliferation via regulating the pRb-E2F pathway.

Authors:  Te Liu; Lengchen Hou; Yongyi Huang
Journal:  Tumour Biol       Date:  2014-04-27

Review 9.  Signaling mechanisms of the epithelial-mesenchymal transition.

Authors:  David M Gonzalez; Damian Medici
Journal:  Sci Signal       Date:  2014-09-23       Impact factor: 8.192

10.  MicroRNA: Biogenesis, Function and Role in Cancer.

Authors:  Leigh-Ann Macfarlane; Paul R Murphy
Journal:  Curr Genomics       Date:  2010-11       Impact factor: 2.236
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  16 in total

Review 1.  MicroRNAs in gynecological cancers: Small molecules with big implications.

Authors:  Sanjeev K Srivastava; Aamir Ahmad; Haseeb Zubair; Orlandric Miree; Seema Singh; Rodney P Rocconi; Jennifer Scalici; Ajay P Singh
Journal:  Cancer Lett       Date:  2017-05-24       Impact factor: 8.679

2.  Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis.

Authors:  Yiming Yang; Di Wang; Kaixiong Tao; Guobin Wang
Journal:  Onco Targets Ther       Date:  2022-05-18       Impact factor: 4.345

3.  Dual strands of the miR-223 duplex (miR-223-5p and miR-223-3p) inhibit cancer cell aggressiveness: targeted genes are involved in bladder cancer pathogenesis.

Authors:  Sho Sugawara; Yasutaka Yamada; Takayuki Arai; Atsushi Okato; Tetsuya Idichi; Mayuko Kato; Keiichi Koshizuka; Tomohiko Ichikawa; Naohiko Seki
Journal:  J Hum Genet       Date:  2018-03-14       Impact factor: 3.172

4.  Regulatory effect of microRNA-223-3p on breast cancer cell processes via the Hippo/Yap signaling pathway.

Authors:  Tonghua Du; Dan Wang; Xiaoyu Wan; Jingwei Xu; Qi Xiao; Bin Liu
Journal:  Oncol Lett       Date:  2021-05-06       Impact factor: 2.967

5.  The effect of circulating miR-223 on surveillance of different cancers: a meta-analysis.

Authors:  Yunfeng Zhang; Jinbo Lin; Wenjie Huang; Yong Cao; Yi Liu; Tieqiang Wang; Weiyi Zhong; Dongli Wang; Rongrong Mao; Xiaoliang Chen
Journal:  Onco Targets Ther       Date:  2017-06-28       Impact factor: 4.147

6.  MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation.

Authors:  Wenqing Zhou; Arpita S Pal; Alan Yi-Hui Hsu; Theodore Gurol; Xiaoguang Zhu; Sara E Wirbisky-Hershberger; Jennifer L Freeman; Andrea L Kasinski; Qing Deng
Journal:  Cell Rep       Date:  2018-02-13       Impact factor: 9.423

Review 7.  miR-223: An Effective Regulator of Immune Cell Differentiation and Inflammation.

Authors:  Peng Jiao; Xing-Ping Wang; Zhuo-Ma Luoreng; Jian Yang; Li Jia; Yun Ma; Da-Wei Wei
Journal:  Int J Biol Sci       Date:  2021-06-04       Impact factor: 6.580

8.  Cellular Retinoic Acid Binding Protein 2 Is Strikingly Downregulated in Human Esophageal Squamous Cell Carcinoma and Functions as a Tumor Suppressor.

Authors:  Qingyuan Yang; Rui Wang; Weifan Xiao; Fenyong Sun; Hong Yuan; Qiuhui Pan
Journal:  PLoS One       Date:  2016-02-03       Impact factor: 3.240

9.  MicroRNA-223 Increases the Sensitivity of Triple-Negative Breast Cancer Stem Cells to TRAIL-Induced Apoptosis by Targeting HAX-1.

Authors:  Xu Sun; Yongqing Li; Meizhu Zheng; Wenshu Zuo; Wenzhu Zheng
Journal:  PLoS One       Date:  2016-09-12       Impact factor: 3.240

Review 10.  Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer.

Authors:  Georgios S Markopoulos; Eugenia Roupakia; Maria Tokamani; Georgia Alabasi; Raphael Sandaltzopoulos; Kenneth B Marcu; Evangelos Kolettas
Journal:  Biomedicines       Date:  2018-03-30
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