Aysenur Deger1, Filiz Ozyigit2, Ozlem Arik3, Fatih Ekici4, Ahmet Cinkaya5, Mahir Tayfur6, Hakki Deger7. 1. Department of Pathology, Faculty of Medicine, Dumlupinar University Kutahya, Turkey. 2. Department of Pharmacology, Faculty of Medicine, Dumlupinar University Kutahya, Turkey. 3. Department of Biostatistics, Faculty of Medicine, Dumlupinar University Kutahya, Turkey. 4. Department of General Surgery, Kutahya Evliya Celebi Training and Research Hospital Kutahya, Turkey. 5. Department of Radiation Oncology, Kutahya Evliya Celebi Training and Research Hospital Turkey. 6. Department of Pathology, Faculty of Medicine, Erzincan University Erzincan, Turkey. 7. Department of Neurosurgery, Kutahya Evliya Celebi Training and Research Hospital Kutahya, Turkey.
Abstract
UNLABELLED: We investigated the effect of clinical features and well-known histomorphological parameters on survival of breast cancer. MATERIAL AND METHODS: 44 patients with invasive ductal carcinoma were included in this study. We investigated the effect of age, breast cancer location (right/left), histological grade, largest diameter of the tumor, lymphovascular and perineural invasion on patient survival. IBM SPSS (Statistical Package for Social Sciences) 20 program was used for statistics. Cox proportional hazard regression model for survival analysis, log-log plot, life function graphs were used. Results were 95% confidence interval, significance (P < 0.05). RESULTS: In univariate analysis, the left breast localization, high histological grade, large tumor size, lymphovascular invasion, perineural invasion has been shown that reduced the overall survival (P < 0.05). In multivariate analysis, only high histological grade, large tumor size and perineural invasion were identified as parameters negatively associated with patient survival (P < 0.05). On univariate and multivariate analysis, age was not associated with survival. CONCLUSION: The above results should be considered in the follow-up and treatment planning of invasive ductal carcinoma patients.
UNLABELLED: We investigated the effect of clinical features and well-known histomorphological parameters on survival of breast cancer. MATERIAL AND METHODS: 44 patients with invasive ductal carcinoma were included in this study. We investigated the effect of age, breast cancer location (right/left), histological grade, largest diameter of the tumor, lymphovascular and perineural invasion on patient survival. IBM SPSS (Statistical Package for Social Sciences) 20 program was used for statistics. Cox proportional hazard regression model for survival analysis, log-log plot, life function graphs were used. Results were 95% confidence interval, significance (P < 0.05). RESULTS: In univariate analysis, the left breast localization, high histological grade, large tumor size, lymphovascular invasion, perineural invasion has been shown that reduced the overall survival (P < 0.05). In multivariate analysis, only high histological grade, large tumor size and perineural invasion were identified as parameters negatively associated with patient survival (P < 0.05). On univariate and multivariate analysis, age was not associated with survival. CONCLUSION: The above results should be considered in the follow-up and treatment planning of invasive ductal carcinomapatients.
Entities:
Keywords:
Breast cancer; histopathological criteria; invasive ductal carcinoma; overall survival
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