Mehmet Baran Karataş1, Göktürk İpek2, Yiğit Çanga1, Barış Güngör1, Kazim Serhan Özcan3, Emre Arugaslan4, Zeki Yüksel Günaydin5, Gündüz Durmuş6, Tolga Onuk1, Koray Kalenderoğlu1, Evliya Akdeniz1, Osman Bolca1. 1. Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital, Istanbul, Turkey. 2. Department of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts. 3. Department of Cardiology, Derince Training and Research Hospital, Kocaeli, Turkey. 4. Department of Cardiology, Sinop State Hospital, Sinop, Turkey. 5. Department of Cardiology, Ordu University, Ordu, Turkey. 6. Department of Cardiology, Arnavutköy State Hospital, Istanbul, Turkey.
Abstract
BACKGROUND: Blood pressure variability (BPV) is a novel parameter related to adverse cardiovascular findings and events, especially in hypertensive patients. The aim of the present study was to investigate the relationship between short-term BPV and ascending aortic dilatation (AAD). HYPOTHESIS: Hypertensive patients with AAD may exhibit higher short-term BPV compared to hypertensive patients with normal diameter ascending aorta and BPV may be correlated with aortic sizes. METHODS: Seventy-six hypertensive patients with AAD and 181 hypertensive patients with a normal-diameter ascending aorta were retrospectively enrolled in the study. Clinical data, echocardiographic characteristics, and 24-hour ambulatory blood pressure monitoring characteristics were compared between the 2 groups. Standard deviation (SD) and Δ of BP were used as parameters of BPV. RESULTS: Although 24-hour mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar between the 2 groups, the SD of SBP and SD of DBP values were significantly higher in AAD patients (17.2 ± 6.8 vs 13.8 ± 3.5, P < 0.01; and 12.1 ± 5.1 vs 10.7 ± 3.1, P = 0.02, respectively). Daytime SD of SBP values were higher in AAD patients, whereas nighttime SD of SBP values did not differ between groups. In multivariate linear regression analysis, 24-hour SD of SBP, 24-hour Δ SBP, daytime SD of SBP, daytime Δ SBP, and left ventricular mass index were independently correlated with aortic size index. CONCLUSIONS: Our study revealed higher levels of short-term BPV in hypertensive patients with AAD. This conclusion warrants further study.
BACKGROUND: Blood pressure variability (BPV) is a novel parameter related to adverse cardiovascular findings and events, especially in hypertensivepatients. The aim of the present study was to investigate the relationship between short-term BPV and ascending aortic dilatation (AAD). HYPOTHESIS: Hypertensivepatients with AAD may exhibit higher short-term BPV compared to hypertensivepatients with normal diameter ascending aorta and BPV may be correlated with aortic sizes. METHODS: Seventy-six hypertensivepatients with AAD and 181 hypertensivepatients with a normal-diameter ascending aorta were retrospectively enrolled in the study. Clinical data, echocardiographic characteristics, and 24-hour ambulatory blood pressure monitoring characteristics were compared between the 2 groups. Standard deviation (SD) and Δ of BP were used as parameters of BPV. RESULTS: Although 24-hour mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar between the 2 groups, the SD of SBP and SD of DBP values were significantly higher in AAD patients (17.2 ± 6.8 vs 13.8 ± 3.5, P < 0.01; and 12.1 ± 5.1 vs 10.7 ± 3.1, P = 0.02, respectively). Daytime SD of SBP values were higher in AAD patients, whereas nighttime SD of SBP values did not differ between groups. In multivariate linear regression analysis, 24-hour SD of SBP, 24-hour Δ SBP, daytime SD of SBP, daytime Δ SBP, and left ventricular mass index were independently correlated with aortic size index. CONCLUSIONS: Our study revealed higher levels of short-term BPV in hypertensivepatients with AAD. This conclusion warrants further study.
Authors: Zhaoyu Wu; Yixuan Li; Peng Qiu; Haichun Liu; Kai Liu; Weimin Li; Ruihua Wang; Tao Chen; Xinwu Lu Journal: Front Cardiovasc Med Date: 2022-06-03