| Literature DB >> 26616942 |
Rui Xing1, Fang Wang2, Le Dong3, A-Ping Zheng1, Li Wang4, Wen-Jin Su1, Ting Lin3.
Abstract
Keggin-type Cu-substituted phosphomolybdic acid (Na7PMo11CuO40, abbreviated as PMo11Cu) was synthesized and characterized. The inhibitory effects of PMo11Cu on mushroom tyrosinase and melanin formation in B16 melanoma cells were studied. The results showed that PMo11Cu could strongly inhibit the activity of tyrosinase, and it was reversible and competitive inhibitor. The IC50 value was estimated to be 0.48 mM for diphenolase activity. PMo11Cu also exhibited inhibitory effects on cell viability, cellular tyrosinase activity and melanin formation in B16 melanoma cells at concentrations ranging from 0 to 200 μM for 24 h. Furthermore, the antimicrobial activities of PMo11Cu against Sarcina lutea, Staphylococcus aureus, Bacillus subtilis and Escherichia coli were investigated. The results showed that PMo11Cu had an obvious antimicrobial activities, and it was more effective against two kinds of coccus than two kinds of bacillus. This study may provide theoretical basis for designing novel effective mushroom tyrosinase inhibitors and extend the use of polyoxometalates in the fields of food preservation and depigmentation.Entities:
Keywords: Antimicrobial activity; Melanin formation; Polyoxometalates; Tyrosinase inhibition
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Year: 2015 PMID： 26616942 DOI： 10.1016/j.foodchem.2015.10.119
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514