Sanne Jespersen1,2, Bo Langhoff Hønge1,2,3, Joakim Esbjörnsson4,5, Candida Medina6, David da Silva Té6, Faustino Gomes Correira6, Alex Lund Laursen2, Lars Østergaard2, Andreas Andersen1, Peter Aaby1,7, Christian Erikstrup3, Christian Wejse1,2,8. 1. Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau. 2. Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. 3. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. 4. Department of Experimental Medical Science, Section of Molecular Virology, Lund University, Lund, Sweden. 5. Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. 6. National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau. 7. Research Center for Vitamins and Vaccines (CVIVA), Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark. 8. GloHAU, Center for Global Health, School of Public Health, Aarhus University, Aarhus, Denmark.
Abstract
OBJECTIVES: Several studies have reported conflicting effects of sex on HIV-1 infection. We describe differences in baseline characteristics and assess the impact of sex on HIV progression among patients at a clinic with many HIV-2 and HIV-1/2 dually infected patients. METHODS: This study utilised a retrospective cohort of treatment-naïve adults at the largest HIV clinic in Guinea-Bissau from 6 June 2005 to 1 December 2013. Baseline characteristics were assessed and the patients followed until death, transfer, loss to follow-up, or 1 June 2014. We estimated the time from the first clinic visit until initiation of ART, death or loss to follow-up using Cox proportional hazard models. RESULTS: A total of 5694 patients were included in the study, 3702 women (65%) and 1992 men (35%). Women were more likely than men to be infected with HIV-2 (19% vs. 15%, P < 0.01) or dually infected with HIV-1/2 (11% vs. 9%, P = 0.02). For all HIV types, women were younger (median 35 vs. 40 years), less likely to have schooling (55% vs. 77%) or to be married (46% vs. 67%), and had higher baseline CD4 cell counts (median 214 vs. 178 cells/μl). Men had a higher age-adjusted mortality rate (hazard rate ratio (HRR) 1.29, 95% confidence interval (CI) 1.09-1.52) and were more often lost to follow-up (HRR 1.27, 95% CI 1.17-1.39). CONCLUSION: Significant differences exist between HIV-infected men and women regardless of HIV type. Men seek treatment at a later stage and, despite better socio-economic status, have higher mortality and loss to follow-up than women.
OBJECTIVES: Several studies have reported conflicting effects of sex on HIV-1 infection. We describe differences in baseline characteristics and assess the impact of sex on HIV progression among patients at a clinic with many HIV-2 and HIV-1/2 dually infectedpatients. METHODS: This study utilised a retrospective cohort of treatment-naïve adults at the largest HIV clinic in Guinea-Bissau from 6 June 2005 to 1 December 2013. Baseline characteristics were assessed and the patients followed until death, transfer, loss to follow-up, or 1 June 2014. We estimated the time from the first clinic visit until initiation of ART, death or loss to follow-up using Cox proportional hazard models. RESULTS: A total of 5694 patients were included in the study, 3702 women (65%) and 1992 men (35%). Women were more likely than men to be infected with HIV-2 (19% vs. 15%, P < 0.01) or dually infected with HIV-1/2 (11% vs. 9%, P = 0.02). For all HIV types, women were younger (median 35 vs. 40 years), less likely to have schooling (55% vs. 77%) or to be married (46% vs. 67%), and had higher baseline CD4 cell counts (median 214 vs. 178 cells/μl). Men had a higher age-adjusted mortality rate (hazard rate ratio (HRR) 1.29, 95% confidence interval (CI) 1.09-1.52) and were more often lost to follow-up (HRR 1.27, 95% CI 1.17-1.39). CONCLUSION: Significant differences exist between HIV-infectedmen and women regardless of HIV type. Men seek treatment at a later stage and, despite better socio-economic status, have higher mortality and loss to follow-up than women.
Authors: Boris K Tchounga; Bo L Hønge; Serge P Eholie; Patrick A Coffie; Sanne Jespersen; Christian Wejse; François Dabis; Gottlieb S Geoffrey; Didier K Ekouevi Journal: AIDS Date: 2016-11-13 Impact factor: 4.177
Authors: Bo Langhoff Hønge; Sanne Jespersen; Johanna Aunsborg; Delfim Vicente Mendes; Candida Medina; David da Silva Té; Alex Lund Laursen; Christian Erikstrup; Christian Wejse Journal: Pan Afr Med J Date: 2016-09-29
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Authors: S Jespersen; F Månsson; J Lindman; C Wejse; C Medina; Z J da Silva; DdS Te; P Medstrand; J Esbjörnsson; B L Hønge Journal: AIDS Res Ther Date: 2020-02-04 Impact factor: 2.250
Authors: Noelle A Benzekri; Jacques F Sambou; Sanou Ndong; Mouhamadou Baïla Diallo; Ibrahima Tito Tamba; Dominique Faye; Jean Philippe Diatta; Khadim Faye; Ibrahima Sall; Fatima Sall; Ousseynou Cisse; Jean Jacques Malomar; Cheikh T Ndour; Papa Salif Sow; Stephen E Hawes; Moussa Seydi; Geoffrey S Gottlieb Journal: AIDS Care Date: 2021-03-08