Konrad Szosland1, Andrzej Lewiński2. 1. Department of Endocrinology and Metabolic Diseases, Polish Mother Memory Hospital, Lodz, Poland. Electronic address: konrad.szosland@szosland.org. 2. Department of Endocrinology and Metabolic Diseases, Polish Mother Memory Hospital, Lodz, Poland; Department of Endocrinology and Metabolic Diseases, Medical University, Lodz, Poland.
Abstract
UNLABELLED: Insulin resistance (IR) a state of decreased sensitivity of target tissues to insulin is suspected usually in obese so can be overlooked in normal weight subjects thus it is important to find optimal method of IR assessment in clinical practice. METHODS: HOMA, HOMA2, QUICKI, Matsuda index were calculated using data obtained from medical history of 130 female subjects - patients of the Department of Endocrinology and Metabolic Diseases, in whom oral glucose tolerance test (OGTT) with parallel insulin concentrations assessment was performed. RESULTS: IR correlated positively with body mass index (BMI) in the entire study group, regardless which of four analyzed IR indices was used. Insulin resistance occurred in the obese as well as in normal weight and underweight subjects. The incidences of IR in the study group varied, depending upon chosen method and adopted cut-off values. CONCLUSIONS: The need for quantitative assessment of IR in clinical practice is apparent. Proper selection of the best method of IR assessment remains a problem. HOMA appears the method of first choice for clinical use. There is an urgent need to establish universal or, at least, national standard cut-off values for IR, to introduce IR assessment in clinical practice.
UNLABELLED: Insulin resistance (IR) a state of decreased sensitivity of target tissues to insulin is suspected usually in obese so can be overlooked in normal weight subjects thus it is important to find optimal method of IR assessment in clinical practice. METHODS: HOMA, HOMA2, QUICKI, Matsuda index were calculated using data obtained from medical history of 130 female subjects - patients of the Department of Endocrinology and Metabolic Diseases, in whom oral glucose tolerance test (OGTT) with parallel insulin concentrations assessment was performed. RESULTS: IR correlated positively with body mass index (BMI) in the entire study group, regardless which of four analyzed IR indices was used. Insulin resistance occurred in the obese as well as in normal weight and underweight subjects. The incidences of IR in the study group varied, depending upon chosen method and adopted cut-off values. CONCLUSIONS: The need for quantitative assessment of IR in clinical practice is apparent. Proper selection of the best method of IR assessment remains a problem. HOMA appears the method of first choice for clinical use. There is an urgent need to establish universal or, at least, national standard cut-off values for IR, to introduce IR assessment in clinical practice.
Authors: Krzysztof C Lewandowski; Justyna Płusajska; Wojciech Horzelski; Ewa Bieniek; Andrzej Lewiński Journal: Endocr Connect Date: 2018-02-07 Impact factor: 3.335
Authors: Krzysztof C Lewandowski; Elżbieta Skowrońska-Jóźwiak; Katarzyna Łukasiak; Katarzyna Gałuszko; Aleksandra Dukowicz; Magdalena Cedro; Andrzej Lewiński Journal: Arch Med Sci Date: 2019-01-30 Impact factor: 3.318