Qingguo Du1, Xueyan Guo2, Xiyang Zhang3, Wenjing Zhou3, Zhuo Liu4, Jianhua Wang1, Tao Zhang1, Zhijun Mao1, Jun Luo5, Tianbo Jin3,6, Chang Liu5. 1. Second Department of General Surgery, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China. 2. Department of Internal Medicine, Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an - China. 3. School of Life Sciences, Northwest University, Xi'an - China. 4. Xidian Group Hospital, Xi'an - China. 5. The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an - China. 6. National Engineering Research Center for Miniaturized Detection Systems, Xi'an - China.
Abstract
PURPOSE: Colorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer mortality, and twin studies have shown that approximately 35% of the variation in susceptibility to CRC involves inherited genetic differences. We sought to investigate potential genetic associations between some single nucleotide polymorphisms (SNPs) and the risk of CRC in the Chinese Han population. METHODS: We conducted a case-control study including 269 cases and 309 controls. Sixteen SNPs associated with CRC risk were selected from previous genome-wide association studies and genotyped using Sequenom MassARRAY technology. Odds ratios and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusting for age and gender. RESULTS: Using the chi-squared test we found that rs9365723 was associated with CRC risk (p = 0.012). With genetic model analysis, the genotype A/G-G/G (OR = 1.50; 95% CI 1.02-2.21; p = 0.038) of rs9365723 showed an increased risk of CRC in the dominant model. Furthermore, we found that rs9365723 was associated with an increased risk only for colon cancer but not rectal cancer (p = 0.009 and p = 0.414, respectively). CONCLUSIONS: Our results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population. Thus, SYNJ2 may play a role in the development of CRC, especially colon cancer.
PURPOSE:Colorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer mortality, and twin studies have shown that approximately 35% of the variation in susceptibility to CRC involves inherited genetic differences. We sought to investigate potential genetic associations between some single nucleotide polymorphisms (SNPs) and the risk of CRC in the Chinese Han population. METHODS: We conducted a case-control study including 269 cases and 309 controls. Sixteen SNPs associated with CRC risk were selected from previous genome-wide association studies and genotyped using Sequenom MassARRAY technology. Odds ratios and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusting for age and gender. RESULTS: Using the chi-squared test we found that rs9365723 was associated with CRC risk (p = 0.012). With genetic model analysis, the genotype A/G-G/G (OR = 1.50; 95% CI 1.02-2.21; p = 0.038) of rs9365723 showed an increased risk of CRC in the dominant model. Furthermore, we found that rs9365723 was associated with an increased risk only for colon cancer but not rectal cancer (p = 0.009 and p = 0.414, respectively). CONCLUSIONS: Our results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population. Thus, SYNJ2 may play a role in the development of CRC, especially colon cancer.
Authors: María Dolores Vázquez-Carretero; Ana Eloisa Carvajal; José Manuel Serrano-Morales; Pablo García-Miranda; Anunciación Ana Ilundain; María José Peral Journal: J Bioenerg Biomembr Date: 2016-11-23 Impact factor: 2.945
Authors: Edwina H Yeung; Weihua Guan; Sunni L Mumford; Robert M Silver; Cuilin Zhang; Michael Y Tsai; Enrique F Schisterman Journal: Epigenomics Date: 2019-01-08 Impact factor: 4.778