Seung Min Lee1, Dae Won Jun2, Yong Kyun Cho3, Ki Seol Jang4. 1. Department of Food and Nutrition, Sungshin Women's University, Seoul, Republic of Korea. 2. Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Republic of Korea. Electronic address: noshin@hanyang.ac.kr. 3. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: choyk2004.cho@samsung.com. 4. Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Republic of Korea.
Abstract
BACKGROUND & AIMS: Serum vitamin D concentration is reduced in patients with non-alcoholic fatty liver disease (NAFLD). Although the mechanism of vitamin D deficiency in liver disease is not fully understood, a few reports have suggested the beneficial effects of vitamin D supplements. The present study investigated changes in serum 25-hydroxy vitamin D level and clinical parameters after total calorie restriction with vitamin D intake reduction in NAFLD patients. METHODS: Newly diagnosed NAFLD patients with elevated aminotransferase levels were chosen for a calorie restriction and weight-reduction program. A total of 82 patients received nutritional education from nutritionists every 2 weeks for 2 months. Serum 25-hydroxy vitamin D level, amount of vitamin D intake, and physical activity were thoroughly investigated. RESULTS: The mean serum 25-hydroxy vitamin D concentration was 13.0 ng/ml. Twenty-nine patients (35.4%) had severe vitamin D deficiency. Patients with a 25-hydroxy vitamin D concentration <10 ng/ml had an increased risk of abdominal obesity (72.4% vs. 47.2%, P = 0.023) and a higher prevalence of metabolic syndrome (69% vs. 42.2%, P = 0.015) compared with patients with 25-hydroxy vitamin D levels >10 ng/ml. Although total energy and vitamin D intake were reduced during the program, serum 25-hydroxy vitamin D levels increased in patients with NAFLD (P < 0.001). Liver enzymes and metabolic parameters also improved, even as vitamin D intake decreased. Serum vitamin D concentration increased with body weight and intrahepatic fat reduction, independent of decreases in vitamin D intake. CONCLUSIONS: Weight loss per increased serum vitamin D level without vitamin D supplementation and improved metabolic parameters in NAFLD.
BACKGROUND & AIMS: Serum vitamin D concentration is reduced in patients with non-alcoholic fatty liver disease (NAFLD). Although the mechanism of vitamin Ddeficiency in liver disease is not fully understood, a few reports have suggested the beneficial effects of vitamin D supplements. The present study investigated changes in serum 25-hydroxy vitamin D level and clinical parameters after total calorie restriction with vitamin D intake reduction in NAFLD patients. METHODS: Newly diagnosed NAFLD patients with elevated aminotransferase levels were chosen for a calorie restriction and weight-reduction program. A total of 82 patients received nutritional education from nutritionists every 2 weeks for 2 months. Serum 25-hydroxy vitamin D level, amount of vitamin D intake, and physical activity were thoroughly investigated. RESULTS: The mean serum 25-hydroxy vitamin D concentration was 13.0 ng/ml. Twenty-nine patients (35.4%) had severe vitamin D deficiency. Patients with a 25-hydroxy vitamin D concentration <10 ng/ml had an increased risk of abdominal obesity (72.4% vs. 47.2%, P = 0.023) and a higher prevalence of metabolic syndrome (69% vs. 42.2%, P = 0.015) compared with patients with 25-hydroxy vitamin D levels >10 ng/ml. Although total energy and vitamin D intake were reduced during the program, serum 25-hydroxy vitamin D levels increased in patients with NAFLD (P < 0.001). Liver enzymes and metabolic parameters also improved, even as vitamin D intake decreased. Serum vitamin D concentration increased with body weight and intrahepatic fat reduction, independent of decreases in vitamin D intake. CONCLUSIONS: Weight loss per increased serum vitamin D level without vitamin D supplementation and improved metabolic parameters in NAFLD.
Authors: A Drori; D Rotnemer-Golinkin; S Avni; A Drori; O Danay; D Levanon; J Tam; L Zolotarev; Y Ilan Journal: BMC Gastroenterol Date: 2017-11-28 Impact factor: 3.067
Authors: Abimbola Adenote; Igor Dumic; Cristian Madrid; Christopher Barusya; Charles W Nordstrom; Libardo Rueda Prada Journal: Can J Gastroenterol Hepatol Date: 2021-04-15
Authors: Jae Yoon Jeong; Dae Won Jun; Sol Ji Park; Joo Hyun Sohn; Sang Gyune Kim; Se Whan Lee; Soung Won Jeong; Moon Young Kim; Won Kim; Jae-Jun Shim; Hyoung Su Kim; Ki Tae Suk; Sang Bong Ahn Journal: Korean J Intern Med Date: 2019-11-12 Impact factor: 2.884