| Literature DB >> 26615887 |
Masahiro Kamo1, Hiroshi Tateishi2, Ryoko Koga3, Yoshinari Okamoto4, Masami Otsuka5, Mikako Fujita6.
Abstract
BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55(Gag) or CA, by means of surface plasmon resonance. The synthesized Biotin-BMMP inhibited HIV-1 replication to a similar extent as BMMP alone, but did not interact with Pr55(Gag) or CA, suggesting that BMMP exerts its activity by a different mechanism.Entities:
Keywords: BMMP; Biotin; CA; HIV-1; Pr55(Gag)
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Year: 2015 PMID： 26615887 DOI： 10.1016/j.bmcl.2015.11.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823